Valuable high-resolution data representing the maneuvering of both individual subject vehicles and adjacent vehicles are available in the era of the connected vehicle systems, which is also referred to as cooperative intelligent transportation systems (C-ITS). C-ITS can share useful traffic information between connected vehicles (CV) and between vehicles and infrastructure in support of vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) wireless communications. An excellent feature of a C-ITS pre-deployment project in Korean freeways that CVs are equipped with an in-vehicle forward collision warning system. This technical support provides a useful opportunity to evaluate crash risks more objectively and scientifically based on the analysis of vehicle interactions, which motivates our study. The purpose of this study is to develop a road safety information system based on the analysis of CV data. The proposed system estimates individual vehicle crash risks based on the crash potential index (CPI) and further utilizes them to develop a methodology for assessing road safety risks on freeways. High CPIs were observed in toll plaza area, recurrent congestion sections, and on and off-ramp areas. An encouraging result showed that the relationship between the estimated CPI and the actual crash frequencies was statistically meaningful. In addition, the impact of the CV market penetration rate (MPR) on the feasibility of the proposed road risk monitoring method was explored by microscopic traffic simulation experiments using VISSIM. A safety evaluation equivalent to 100 % MPR was obtainable with 30 % MPR. The outcomes of this study are expected to be utilized as fundamental to support the development of novel road risk monitoring systems in C-ITS environments.
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http://dx.doi.org/10.1016/j.aap.2021.105972 | DOI Listing |
Biochem Biophys Res Commun
January 2025
Biofuels Institute, School of Environment and Safety Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China; School of Emergency Management, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China; Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology, Suzhou, 215009, China. Electronic address:
The biomethanation process is widely recognized as a significant approach to mitigating carbon dioxide emissions while simultaneously generating methane. However, only a few microorganisms that required intricate culturing conditions were identified for biomethanation. Here, Escherichia coli that featured easy cultivation and versatile chassis was genetically modified for biomethanation for the first time.
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January 2025
Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, China.
Purpose: Glioblastoma (GBM), the most common malignant tumor of the central nervous system (CNS) in adults, continues to result in poor survival rates despite standard treatment. Advancements in understanding GBM's molecular complexity have increased interest in targeted therapeutic approaches. This retrospective, single-center, single-arm study combined nimotuzumab and bevacizumab with radiotherapy (RT) and temozolomide (TMZ) for the treatment of newly diagnosed GBM.
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January 2025
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Minimal Invasive Intervention, Sun Yat-sen University Cancer Center, 651, Dongfeng East Road, Guangzhou 510060, P.R. China.
Background: Transarterial chemoembolization (TACE) is an effective and safe downstaging therapy for hepatocellular carcinoma (HCC). However, the selection of sequential therapeutic modalities is still controversial.
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Ther Adv Med Oncol
January 2025
Department of Medical Oncology, Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, China.
Background: For non-small-cell lung cancer (NSCLC) patients who progressed after first-line chemotherapy, immunotherapy targeting programmed cell death (ligand) 1 has shown promising activity. However, the activity is relatively limited in patients harboring epidermal growth factor receptor (EGFR) mutations.
Objectives: This study aimed to evaluate the efficacy and safety of camrelizumab plus famitinib in previously treated patients with locally advanced and metastatic NSCLC.
Environ Sci Ecotechnol
January 2025
Earth Systems and Global Change Group, Environmental Sciences Department, Wageningen University & Research, Droevendaalsesteeg 4, Wageningen, 6708 PB, the Netherlands.
Antibiotics are extensively used in livestock production to prevent and treat diseases, but their environmental impact through contamination of rivers and groundwater is a growing concern. The specific antibiotics involved, their sources, and their geographic distribution remain inadequately documented, hindering effective mitigation strategies for river and groundwater pollution control caused by livestock production. Here we develope the spatially explicit MARINA-Antibiotics (China-1.
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