AI Article Synopsis
- Tumor cell vasculogenic mimicry (VM) allows aggressive cancer cells to create their own vascular networks, contributing to poor patient outcomes and is found in various types of tumors.
- The presence of VM is linked to higher tumor grades, faster disease progression, invasion, and metastasis.
- Understanding the molecular mechanisms and tumor microenvironment related to VM may lead to improved anticancer therapies and insights into treatment resistance.
Article Abstract
Tumor cell vasculogenic mimicry (VM), also dubbed vascular mimicry, describes the plasticity of aggressive cancer cells forming de novo vascular networks and is associated with the malignant phenotype and poor clinical outcome. VM is described in a plethora of tumors, including carcinomas, sarcomas, glioblastomas, astrocytomas and melanomas. The presence of VM is associated with a high tumor grade, short survival, invasion and metastasis. A variety of molecular mechanisms and signal pathways participates in VM induction and formation. Due to VM's contribution on tumor progression, more VM-related strategies are being utilized for anticancer treatment. After describing the main features of VM, this review will outline the importance of the tumor microenvironment during this process, and highlight the predominant molecular targets and signaling pathways involved. These data will make it possible to discuss the importance of VM-associated mediators in antitumor therapy and how it could allow to better understand the resistance to anticancer therapy.
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| http://dx.doi.org/10.1016/j.pharmthera.2021.107805 | DOI Listing |
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