A highly regio- and stereoselective method was developed for the preparation of -alkenylpyrazoles and chromenopyrazoles by the reaction of -tosylhydrazones and salicyl -tosylhydrazones with alkynes under neat conditions in the presence of La(OTf). The present study was found to be efficient and convenient for direct access to -alkenylpyrazoles and chromenopyrazoles through C-C, C-N, and C-O bond forming reactions. Structure assignment of -alkenylpyrazole compound was confirmed by X-ray analysis.
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Direct Access for the Regio- and Stereoselective Synthesis of -Alkenylpyrazoles and Chromenopyrazoles.
J Org Chem
February 2021
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
A highly regio- and stereoselective method was developed for the preparation of -alkenylpyrazoles and chromenopyrazoles by the reaction of -tosylhydrazones and salicyl -tosylhydrazones with alkynes under neat conditions in the presence of La(OTf). The present study was found to be efficient and convenient for direct access to -alkenylpyrazoles and chromenopyrazoles through C-C, C-N, and C-O bond forming reactions. Structure assignment of -alkenylpyrazole compound was confirmed by X-ray analysis.
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