AI Article Synopsis
- Subcellular localization of long noncoding RNAs (lncRNAs) is crucial for their function, given that they are functional RNA molecules larger than 200 nucleotides that do not encode proteins.
- Research has discovered numerous lncRNAs involved in various cellular processes, making understanding their localization vital for comprehending their roles in biology.
- This review highlights current knowledge on lncRNA localization, factors affecting it, emerging themes like isoforms and phase separation bodies, and identifies gaps in research that present new opportunities for exploration.
Article Abstract
Subcellular localization of RNAs has gained attention in recent years as a prevalent phenomenon that influences numerous cellular processes. This is also evident for the large and relatively novel class of long noncoding RNAs (lncRNAs). Because lncRNAs are defined as RNA transcripts >200 nucleotides that do not encode protein, they are themselves the functional units, making their subcellular localization critical to their function. The discovery of tens of thousands of lncRNAs and the cumulative evidence involving them in almost every cellular activity render assessment of their subcellular localization essential to fully understanding their biology. In this review, we summarize current knowledge of lncRNA subcellular localization, factors controlling their localization, emerging themes, including the role of lncRNA isoforms and the involvement of lncRNAs in phase separation bodies, and the implications of lncRNA localization on their function and on cellular behavior. We also discuss gaps in the current knowledge as well as opportunities that these provide for novel avenues of investigation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816648 | PMC |
| http://dx.doi.org/10.1083/jcb.202009045 | DOI Listing |
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