AI Article Synopsis
- - A new iron-catalyzed reaction has been created that rearranges 1,2,3,4-tetrazole using a unique mechanism that involves metalloradical activation rather than typical methods.
- - This method allows for the production of various complex nitrogen-containing compounds, showcasing its versatility.
- - The research highlights its potential in medicinal chemistry and drug discovery, demonstrated by a quick synthesis of a bioactive molecule.
Article Abstract
An iron-catalyzed denitrogenative rearrangement of 1,2,3,4-tetrazole is developed over the competitive C(sp )-H amination. This catalytic rearrangement reaction follows an unprecedented metalloradical activation mechanism. Employing the developed method, a wide number of complex-N-heterocyclic product classes have been accessed. The synthetic utility of this radical activation method is showcased with the short synthesis of a bioactive molecule. Collectively, this discovery underlines the progress of radical activation strategy that should find wide application in the perspective of medicinal chemistry, drug discovery and natural product synthesis research.
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| http://dx.doi.org/10.1002/anie.202014950 | DOI Listing |
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