AI Article Synopsis
- The study aimed to examine how changes in N-acetylaspartate/creatine (NAA/Cr) and the relative apparent diffusion coefficient (rADC) correlate with secondary brain injury (SBI) in patients with spontaneous intracerebral hemorrhage (SICH).
- 108 patients diagnosed with SICH underwent magnetic resonance spectroscopy (MRS) and diffusion weighted imaging (DWI) two days after admission, and were divided into SBI and control groups based on the presence of SBI factors.
- Results showed that both NAA/Cr and rADC levels were significantly lower in the SBI group compared to controls, and these measures were identified as risk factors for SBI, which can worsen brain injury and affect patient outcomes.
Article Abstract
Objective: To investigate the correlations between the changes of N-acetylaspartate/creatine (NAA/Cr) detected by magnetic resonance spectroscopy (MRS), and of the relative apparent diffusion coefficient (rADC) detected by diffusion weighted imaging (DWI) and the occurrence and outcome of secondary brain injury (SBI) in patients with spontaneous intra-cerebral hemorrhage (SICH).
Methods: One hundred and eight SICH patients diagnosed by CT from January 2014 to December 2019 in the First People's Hospital of Huzhou were selected as the research objects. MRS and DWI examinations were performed on day 2 after admission. The body temperature, blood pressure, blood glucose, blood sodium, arterial oxygen partial pressure (PaO) and other indexes were continuously monitored. The patients were divided into two groups: SBI group (46 cases) and control group (62 cases) according to whether there were secondary brain injury factors (SBIF). The differences in NAA/Cr and rADC of the edema area and Glasgow outcome score (GOS) after 6 months were compared between the two groups; multivariate Logistic regression analysis was used to analyze the risk factors of SBI.
Results: The NAA/Cr and rADC of perihematoma edema area and GOS after 6 months in SBI group were significantly lower than those in control group [NAA/Cr: 1.64±0.35 vs. 1.87±0.41, rADC: 2.57±0.39 vs. 2.75±0.45, GOS after 6 months (points): 3.47±0.59 vs. 3.76±0.65], with significant differences (all P < 0.05). Logistic regression analysis showed that NAA/Cr and rADC were the risk factors for the occurrence of SBI [odds ratio (OR) values were 0.172, 0.343, 95% confidence intervals (95%CI) were 0.048-0.609 and 0.118-0.996, respectively, both P < 0.05].
Conclusions: MRS combined with DWI has a certain value in predicting SBI after SICH. SBI can aggravate brain injury and affect the prognosis of patients. SBI should be actively prevented and intervention, carried out.
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| http://dx.doi.org/10.3760/cma.j.cn121430-20200331-00247 | DOI Listing |
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