AI Article Synopsis
- The study focused on the role of HER2 protein overexpression and gene amplification in feline pulmonary carcinomas, aiming to understand its significance in lung cancer.
- Thirteen pulmonary carcinomas were examined, revealing that HER2 was overexpressed in 15% of cases, while 27% showed gene amplification.
- The findings suggest a potential link between HER2 overexpression and gene amplification in feline lung cancer, but further research is required to validate HER2 as a target for new treatments.
Article Abstract
HER2 is overexpressed, amplified, and mutated in a subset of human lung cancer. The aim of this study was to investigate HER2 protein overexpression and gene amplification in feline pulmonary carcinomas. Thirteen pulmonary carcinomas were selected and TTF-1 and HER2 expression was evaluated by immunohistochemistry. Fluorescence in situ hybridization (FISH) was performed with a probe and a BAC probe for the feline chromosome E1p1.12-p1.11 region. Twelve adenocarcinomas and 1 squamous cell carcinoma were diagnosed. TTF-1 was positive in 7 carcinomas (58%). HER2 was overexpressed in 2 (15%), equivocal in 5 (38%), and negative in 6 cases (46%). FISH analysis of was indeterminate in 2 cases. Three pulmonary carcinomas (27%) had amplification and 8 cases were not amplified (73%). The significant correlation between HER2 protein overexpression and gene amplification are promising preliminary data, but study of additional cases is needed to confirm HER2 as a target for possible innovative treatments.
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| http://dx.doi.org/10.1177/0300985820988147 | DOI Listing |
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