The common sense model of illness self-regulation outlines the dynamic processes by which individuals perceive, interpret, and respond to health threats and illness-related information. An extended version of the model is proposed, which specifies additional constructs and processes to explain how lay perceptions of health threats impact coping responses and health-related outcomes. The extended model provides detail on: (a) the mediating process by which individuals' illness representations relate to illness outcomes through adoption of coping procedures; (b) how illness representations are activated by presentation of health-threatening stimuli; (c) behavioral and treatment beliefs as determinants of coping procedures and illness outcomes alongside illness representations; and (d) effects of moderators of relations between cognitive representations, coping procedures, and illness outcomes. The extended model sets an agenda for future research that addresses knowledge gaps regarding how individuals represent and cope with health threats, and may inform effective illness-management interventions. We identify the kinds of research required to provide robust evidence for the extended model propositions. We call for research that employs incipient illness samples, utilizes designs that capture dynamic processes in the model such as cross-lagged panel and intervention designs, and adopts illness-specific measures of coping procedures rather than relying on generic instruments.
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http://dx.doi.org/10.1080/17437199.2021.1878050 | DOI Listing |
Aging Cell
January 2025
Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, New York, USA.
Declines in lysosomal acidification and function with aging are observed in organisms ranging from yeast to humans. V-ATPases play a central role in organelle acidification, and V-ATPase activity is regulated by reversible disassembly in many different settings. Using the yeast Saccharomyces cerevisiae as a replicative aging model, we demonstrate that V-ATPases disassemble into their V and V subcomplexes in aging cells, with release of V subunit C (Vma5) from the lysosome-like vacuole into the cytosol.
View Article and Find Full Text PDFOpen Mind (Camb)
January 2025
Department of Computer Science, University of Toronto, Toronto, Canada.
The lexicon is an evolving symbolic system that expresses an unbounded set of emerging meanings with a limited vocabulary. As a result, words often extend to new meanings. Decades of research have suggested that word meaning extension is non-arbitrary, and recent work formalizes this process as cognitive models of semantic chaining whereby emerging meanings link to existing ones that are semantically close.
View Article and Find Full Text PDFProstate Int
September 2024
Department of Urology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Japan.
Background: Despite providing valuable staging and prognostic information, the therapeutic benefit of pelvic lymph node dissection (PLND) remains uncertain. We sought to assess the effect of extended PLND (ePLND) on the biochemical recurrence (BCR) of patients with National Comprehensive Cancer Net (NCCN) high- or very high-risk prostate cancer treated via robot-assisted radical prostatectomy (RARP).
Methods: We used a multi-institutional database (six centers) to assess 989 patients who underwent RARP from 2014 to 2022 with or without ePLND, among which 699 patients underwent BCR analysis.
ACS Pharmacol Transl Sci
January 2025
Department of Genetics and Microbiology, Charles University and Research Center BIOCEV, Pru°myslová 595, Vestec 252 50, Czech Republic.
The 26S proteasome degrades the majority of cellular proteins and affects all aspects of cellular life. Therefore, the 26S proteasome abundance, proper assembly, and activity in different life contexts need to be precisely controlled. Impaired proteasome activity is considered a causative factor in several serious disorders.
View Article and Find Full Text PDFSurg Open Sci
January 2025
Division of Breast Cancer Surgery, Department of Surgery, National Cancer Institute, Bangkok, Thailand.
Background: Breast cancer is the most common cancer among women. In response to the need to hospital stays and minimize waiting time for surgery, particularly during the COVID-19 pandemic, the National Cancer Institute developed the One Day Surgery with Breast cancer Home Recovery program (ODS BHR NCI). The aim of study is to assess the success rate of breast cancer surgeries conducted through this program and to evaluate the incidence of complications.
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