A chemical investigation of Makino identified four compounds. On the basis of spectroscopic data, they were determined to be -pimarane-type diterpenoids and their analogues, among which were two previously undescribed compounds, Sigesbeckia K () and Sigesbeckia L (). The anti-inflammatory effects of these compounds were evaluated by testing their inhibition of LPS-induced NO production in BV2 microglial cells, which revealed potential inhibitory effects with IC value at 62.56 μM and compared with the positive control minocycline (IC 32.84 μM).
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