HIV-1 evolved from SIV during cross-species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV-1 Group M using humanized mice. High viral loads, rapid CD4 T-cell decline, and non-synonymous substitutions were identified throughout the viral genome suggesting viral adaptation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177655 | PMC |
| http://dx.doi.org/10.1111/jmp.12485 | DOI Listing |
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