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Contemporary Perspectives in Critical Care of Neuroleptic Malignant Syndrome.
Neurocrit Care
January 2025
Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA.
Background: Neuroleptic malignant syndrome (NMS) is a psychiatric-neurologic emergency that may require intensive care management. There is a paucity of information about NMS as a critical illness. We reviewed the Mayo Clinic experience.
View Article and Find Full Text PDFTyphoid & paratyphoid vaccine development in the laboratory: a review & in-country experience.
Indian J Med Res
December 2024
ICMR-National Institute of Occupational Health, Ahmedabad, Gujarat, India.
Enteric fever is caused by the infection of Gram-negative bacteria, Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi (S. Paratyphi) A, B and C, through contaminated food and water. The disease almost exclusively affects the populations living in low- and middle-income countries, with the World Health Organization Southeast Asian Region (WHO SEAR) having the highest endemicity.
View Article and Find Full Text PDFVirus-Induced Voracity: Uncovering Hyperphagia Post-Herpes Simplex Virus Type 1.
Case Rep Neurol
October 2024
Department of Neurology, Institute of Medical Sciences Banaras Hindu University, Varanasi, India.
Article Synopsis
- HSV-1 is a major cause of fatal encephalitis, often presenting with symptoms like fever, headache, seizures, and focal neurological deficits; hyperphagia, an increased appetite, is a rare complication.
- A 25-year-old woman with a history of meningitis experienced severe neurological symptoms, MRI showed abnormalities in her temporal lobes, and CSF analysis confirmed an HSV-1 infection, leading to treatment with acyclovir.
- The case illustrates that hyperphagia can occur as a standalone symptom of HSV encephalitis, highlighting the need for specialized treatment approaches and the importance of early diagnosis to avoid serious complications.
Epidemiology and clinical characteristics of Aeromonas-associated gastroenteritis in Northern Israel: Insights and implications for public health.
Diagn Microbiol Infect Dis
December 2024
Infectious Diseases Unit, Ha'emek Medical Center, Afula, Israel; Rappaport Faculty of Medicine, The Technion-Israel Institute of Technology, Haifa, Israel.
Article Synopsis
- The study investigates the role of Aeromonas spp. in gastroenteritis, noting its controversial status due to differing symptoms and prevalence in symptomatic versus asymptomatic patients.
- Conducted in Northern Israel, it found that 4.24%-4.81% of patients with Aeromonas-associated gastroenteritis (AAG) and 4.9% of asymptomatic individuals had Aeromonas in their stools, raising questions about its pathogenicity.
- Compared to Campylobacter-associated gastroenteritis (CAG) patients, AAG patients experienced significantly less severe symptoms, and certain factors like recent dining out and longer diarrhea were identified as predictors for AAG.
Neutrophil-to-ferritin ratio can predict hematological causes of fever of unknown origin.
Sci Rep
October 2024
Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Article Synopsis
- Despite advances in diagnostic methods, identifying the cause of fever of unknown origin (FUO) is challenging, especially in cases of hematological malignancies that often have poor outcomes due to delayed diagnosis.
- A study analyzed medical records of 100 FUO patients from 2010 to 2023, finding that hematological conditions were present in 26 patients, with distinctive lab marker patterns that aided differentiation from other causes.
- The research highlighted the neutrophil-to-ferritin ratio (NFR) as an effective and inexpensive predictor for hematological etiology, providing a potential early diagnostic tool for clinicians managing FUO cases.
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