Objective: To determine if there is a relationship between the levels of serum uric acid and the different Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages (1-4) classified by the severity of the airflow limitation in patients with stable chronic obstructive pulmonary disease (COPD).
Methods: Electronic databases, including PubMed®, Embase®, Web of Science™ and China National Knowledge Infrastructure (CNKI), were searched from inception to December 2018. Observational studies that reported serum uric acid levels in stable COPD patients were included. Two investigators independently extracted data and RevMan version 5.3 was used to carry out the statistical analyses.
Results: Seven studies with 932 stable COPD patients and 401 healthy control subjects were included in this meta-analysis. Serum uric acid levels were significantly higher in stable COPD patients compared with healthy control subjects (mean difference [MD] 1.91, 95% confidence interval [CI] 1.55, 2.28). Serum uric acid levels were significantly lower in the GOLD 1+2 subgroup compared with the GOLD 3+4 subgroup (MD -1.39, 95% CI -1.63, -1.15).
Conclusion: Serum uric acid might be a useful biomarker for identifying disease severity in stable COPD patients, but further studies are needed to confirm this finding.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816533 | PMC |
| http://dx.doi.org/10.1177/0300060520983705 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Therapeutic Effects of Tea Polyphenols on Renal Damage Induced by High Uric Acid.
Curr Med Chem
January 2025
Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Background: Hyperuricemia (HUA) is a condition characterized by excessive uric acid production and/or inadequate uric acid excretion due to abnormal purine metabolism in the human body. Uric acid deposits resulting from HUA can lead to complications such as renal damage. Currently, drugs used to treat HUA lack specificity and often come with specific toxic side effects.
View Article and Find Full Text PDFTigulixostat Alleviates Hyperuricemic Nephropathy by Promoting M2 Macrophage Polarization.
J Inflamm Res
January 2025
Department of Internal Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, People's Republic of China.
Purpose: Serum uric acid (SUA) is primarily produced through the hydrolysis of purines in the liver, with its excretion largely handled by the kidneys. Urate transporter 1 (URAT1) inhibitors are known to enhance uric acid elimination via the kidneys, but they also increase the risk of kidney stone formation. Currently, xanthine oxidase (XO) inhibitors are the predominant uric-lowering medications on the market.
View Article and Find Full Text PDFThe role of resistin and adiponectin ratios with uric acid in assessing metabolic syndrome in type 2 diabetes.
Mol Cell Biochem
January 2025
International Society of Engineering Science and Technology, Nottingham, UK.
Metabolic syndrome (MetS) is a growing global healthcare burden. Patients with type 2 diabetes mellitus (T2DM) are more likely to acquire MetS than the general population. Recent research suggests that the interaction of adipose tissue products, such as adiponectin resistin and uric acid, is essential in MetS onset.
View Article and Find Full Text PDFAssociation between serum uric acid, hyperuricemia and low muscle mass in middle-aged and elderly adults: A national health and nutrition examination study.
PLoS One
January 2025
School of Nursing, Chengdu Medical College, Chengdu, Sichuan, China.
Backgrounds: Recent research suggests that uric acid, as a metabolite with antioxidant properties, may affect muscle function and health. However, the association between serum uric acid (SUA) and low muscle mass remains relatively obscure. This study focuses on the association between SUA and low muscle mass in a middle-aged and elderly population in the United States.
View Article and Find Full Text PDFSuccessful Management of Acetamiprid Intoxication in a Captive Eurasian Goshawk ().
J Avian Med Surg
January 2025
Ennetseeklinik für Kleintiere, Exotic Pet Department, 6331 Hünenberg, Zug, Switzerland.
A captive, 1-year-old, male Eurasian goshawk () weighing 0.85 kg and owned by a falconer was presented with a history of acute onset of weakness, dyspnea, diarrhea, and regurgitation of a fresh-thawed pigeon contaminated with acetamiprid, an insecticide used in the raptor enclosure. The raptor had eaten the contaminated pigeon approximately 10-12 hours earlier.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!