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Bioactive isocoumarins isolated from a mangrove-derived fungus sp. MGP11. | LitMetric

Bioactive isocoumarins isolated from a mangrove-derived fungus sp. MGP11.

Nat Prod Res

Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.

Published: March 2022

Two new isocoumarins penicimarins L-M (), along with seven known analogues () were isolated from the mangrove-derived fungus sp. MGP11. Compounds - were established by spectroscopic methods and comparison of their circular dichroism (CD) spectra with the literature. All isolated compounds were evaluated for antioxidant and -glucosidase inhibitory activities. Compound had better antioxidant activity (IC = 4.6 μM) than positive control trolox (IC = 12.9 μM). Compounds , and exhibited -glucosidase inhibitory activity with the IC values of 776.5, 683.7 and 868.7 μM, respectively.[Formula: see text].

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http://dx.doi.org/10.1080/14786419.2021.1873981DOI Listing

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