Influence of adrenergic and cholinergic mechanisms in baclofen induced analgesia.

Gen Pharmacol

Departamento de Ciencias Fisiologicas, Universidad de Concepcion, Chile.

Published: April 1988

1. Baclofen induced analgesia was confirmed by means of the mouse hot plate test. 2. Physostigmine significantly increased the response to baclofen whilst neostigmine was ineffective. Baclofen analgesia was reduced by atropine. 3. The response to baclofen was increased by the administration of tolazoline, propranolol and nadolol. In contrast, the analgesic response to morphine was attenuated by the antiadrenergic drugs phenoxybenzamine, tolazoline and nadolol.

Download full-text PDF

Source
http://dx.doi.org/10.1016/0306-3623(88)90010-9DOI Listing

Publication Analysis

Top Keywords

baclofen induced
8
induced analgesia
8
response baclofen
8
baclofen
5
influence adrenergic
4
adrenergic cholinergic
4
cholinergic mechanisms
4
mechanisms baclofen
4
analgesia baclofen
4
analgesia confirmed
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!