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Fuzheng Jiedu decoction alleviates H1N1 virus-induced acute lung injury in mice by suppressing the NLRP3 inflammasome activation.
J Ethnopharmacol
December 2024
The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China; Chinese Medicine Guangdong Laboratory, Guangdong, Hengqin, 519031, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou 510120, China. Electronic address:
Ethnopharmacological Relevance: Severe influenza, marked by excessive cytokine production, is a major contributor to death in hospitalized individuals. Fuzheng Jiedu decoction (FZJDD), an effective traditional Chinese herbal recipe, has demonstrated promising results in combating the COVID-19 pandemic by reducing mortality and improving Symptoms, and has exhibited anti-inflammatory properties in both clinical trials and laboratory research. Given that pneumonia is a common outcome of SARS-CoV-2 and H1N1 virus infections, we hypothesized that FZJDD may also have therapeutic effects on influenza-related pneumonia and acute lung injury (ALI).
View Article and Find Full Text PDFAn agent based simulation of COVID-19 history in Catalonia using extensive real datasets.
Sci Rep
December 2024
DIME, University of Genova, via all'Opera Pia 15, 16145, Genova, Italy.
During the COVID-19 pandemic, effective public policy interventions have been crucial in combating virus transmission, sparking extensive debate on crisis management strategies and emphasizing the necessity for reliable models to inform governmental decisions, particularly at the local level. Leveraging disaggregated socio-demographic microdata, including social determinants, age-specific strata, and mobility patterns, we design a comprehensive network model of Catalonia's population and, through numerical simulation, assess its response to the outbreak of COVID-19 over the two-year period 2020-21. Our findings underscore the critical importance of timely implementation of broad non-pharmaceutical measures and effective vaccination campaigns in curbing virus spread; in addition, the identification of high-risk groups and their corresponding maps of connections within the network paves the way for tailored and more impactful interventions.
View Article and Find Full Text PDFBehaviorally informed digital campaigns and their association with social media engagement and COVID-19 vaccine uptake in Belize.
BMC Glob Public Health
October 2024
Ministry of Health and Wellness, 762G+6W3, East Block Building, Independence Plaza, Belmopan, Belize.
Background: Increasing vaccination coverage was key to curbing the COVID-19 pandemic globally. However, lack of trust in the vaccine and fear of side effects in regions like the Caribbean resulted in a low uptake despite enough vaccine supply.
Methods: We conducted two correlational analyses and one experiment between five sequential behaviorally informed Facebook campaigns, social media performance outcomes, and district-level vaccination data.
Pediatric firearm injuries and socioeconomic vulnerability before and during the COVID-19 pandemic.
Am J Emerg Med
November 2024
Division of Emergency Medicine, Boston Children's Hospital, Boston, MA, USA. Electronic address:
Background: Pediatric firearm injuries disproportionately affect groups experiencing socioeconomic disadvantage. Firearm injuries increased during the COVID-19 pandemic, but the impact on communities by degree of socioeconomic disadvantage is unknown. We examined the association between socioeconomic vulnerability and change in pediatric firearm injuries before versus during the pandemic.
View Article and Find Full Text PDFEvaluating the feasibility and attitudes towards SARS-CoV-2 self-testing in a rural population in Zimbabwe: a cross-sectional survey.
BMJ Open
November 2024
Tackling Infections to Benefit Africa (TIBA) Partnership, The University of Edinburgh, Edinburgh, UK.
Objectives: The widespread adoption of self-testing for SARS-CoV-2 has proven effective in curbing the virus' spread, particularly in Western countries. However, significant knowledge gaps persist regarding the feasibility, acceptance and factors influencing the uptake of self-testing in low-resource areas, notably rural Africa. Our aim was to assess the willingness and capability of rural Zimbabwean participants to self-diagnose COVID-19 using rapid lateral flow tests (LFTs) and adhere to post-positive test guidelines.
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