A paraneoplastic syndrome exacerbated by checkpoint inhibition therapy.

Proc (Bayl Univ Med Cent)

Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Published: October 2020

Polymyalgia rheumatica is a disease characterized by systemic inflammation of the proximal muscles and pain in the hips and shoulders, but when this disease occurs contemporaneously with malignancy, there is a possibility of it being a paraneoplastic syndrome. With the advent of immunotherapies to treat various cancers, immune-related adverse events from these therapies are recognized as de novo findings or as flares of an underlying existing rheumatic disease. In this report, we present a case of polymyalgia rheumatica presenting as a paraneoplastic syndrome that was exacerbated during therapy with immune checkpoint inhibitors for recurrent melanoma.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785140PMC
http://dx.doi.org/10.1080/08998280.2020.1824962DOI Listing

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