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http://dx.doi.org/10.1016/j.remn.2020.11.010 | DOI Listing |
Cancer Biother Radiopharm
November 2024
Department of Clinical Sciences Lund, Section for Oncology, Lund University, Lund, Sweden.
Prostate-specific membrane antigen (PSMA) is a target for diagnostic positron emission tomography (PET)-tracers and radiopharmaceutical therapy (RPT), for example, [Lu]Lu-PSMA-617, in prostate cancer. This autoradiography study investigates [Lu]Lu-PSMA-617 intratumoral distribution over time, compared with PSMA expression, proliferation (Ki67), and [Ga]Ga-PSMA-11, [F]F-PSMA-1007, [F]-fluorodeoxyglucose, and [F]-fluorocholine distribution. Mice with LNCaP, 22Rv1, or PC-3 PIP xenografts got [Lu]Lu-PSMA-617 i.
View Article and Find Full Text PDFDiagnostics (Basel)
November 2024
Department of Nuclear Medicine and Endocrinology, University Hospital Salzburg, Muellner Hauptstrasse 48, 5020 Salzburg, Austria.
: Primary hyperparathyroidism (PHPT) is associated with normal or elevated calcium levels and affects bone mineral density. The proportion of cases predisposed to metabolic bone disease is unknown in patients with PHPT. The aim of this study was to assess bone mineral density and bone quality in patients with normo- or hypercalcemic primary hyperparathyroidism undergoing baseline parathyroid gland assessment with [F]fluorocholine PET/CT imaging.
View Article and Find Full Text PDFEurasian J Med
April 2024
Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia Faculty of Medicine and Health Science, Selangor, Malaysia.
The utility of the [18]F fluorodeoxyglucose positron emission tomography-computed tomography ([18]F FDG PET-CT) marker for breast cancer is well established. Given its limitations in localizing FDG-negative malignant tumors, the expression of [18]F-fluorocholine ([18]-FCH) may potentially be helpful to improve the overall accuracy in evaluating breast cancer. This study determined the potential of [18]- FCH PET CT as a potential marker in assessing breast cancer phenotypes.
View Article and Find Full Text PDFNucl Med Commun
November 2024
Department of Nuclear Medicine and Radiology, .
Objective: 18 F-fluorocholine PET/CT is considered the imaging gold standard for detection of hyperfunctioning parathyroid glands . However, increased uptake might also occur in the thyroid gland. The aim of our study was to assess the incidence and significance of 18 F-fluorocholine uptake in the thyroid gland in patients with hyperparathyroidism.
View Article and Find Full Text PDFDiagnostics (Basel)
July 2024
Division of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.
Here, we describe the case of a 43-year-old male patient with a metastatic parathyroid carcinoma who underwent dual-tracer whole-body positron emission tomography/computed tomography (PET/CT) with [F]fluorocholine and fluorodeoxyglucose ([F]FDG) for staging. [F]FDG PET/CT detected multiple cervical and mediastinal lymph nodal lesions with increased tracer uptake, whereas [F]fluorocholine PET/CT detected increased tracer uptake on cervical and mediastinal lymph nodal lesions and bone and lung lesions with a better evaluation of metastatic spread. Due to these imaging findings, the patient underwent systemic treatment with chemotherapy.
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