AI Article Synopsis
- The study aimed to analyze levels of proinflammatory cytokines in diabetic arthropathy patients and their potential impact on this condition.
- 118 patients were assessed, categorized by diabetes type and arthropathy severity, with serum levels of specific cytokines (IL-1, TNF-α, IL-6) measured via immunoassay.
- Results showed significantly elevated TNF-α and IL-6 levels in diabetic arthropathy patients, with a direct relationship between cytokine levels and joint damage severity, indicating these cytokines as possible markers for arthropathy progression in diabetes.
Article Abstract
Objective: The aim: Of our work was to study the level of proinflammatory cytokines in patients with diabetic arthropathy and to investigate their possible effect on the development of this complication.
Patients And Methods: Materials and methods: 118 patients were examined, which were divided into groups by type of diabetes, the presence and severity of diabetic arthropathy. The content of IL-1, TNF-α, IL-6 and receptors to S IL-6-R in serum was determined by immunoassay.
Results: Results: In patients with diabetic arthropathy, levels of TNF-α (with type 1 diabetes 44.5%, type 2 diabetes 42.9%) and IL-6 (with type 1 diabetes 52.1%, with diabetes 2 types by 64.4%) significantly increased. There is a direct correlation between the severity of joint damage and the level of TNF-α and IL-6. For IL -1, receptors for S IL-6-R have not been detected.
Conclusion: Conclusions: The chances of detecting arthropathy with type 1 diabetes with increasing TNF levels increase by 1.7 times, with an increase in IL-6 by 1.5 times. For type 2 diabetes, it is 1.8 and 1.3 times, respectively. Thus, TNF-α and IL-6 may be markers of the presence and progression of arthropathy in patients with diabetes mellitus.
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