We investigated the characteristics of patients with pertussis who did not receive preschool vaccination boosters. Fifteen patients with laboratory-confirmed pertussis and 29 pertussis-negative patients were compared. All pertussis-positive patients, but only 17% of pertussis-negative patients, were elementary school age and older. There is a need to study the utility of routine preschool pertussis vaccine booster in Japan.
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Front Public Health
December 2024
Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Background: Age plays a significant role in susceptibility to enterotoxigenic (ETEC) infections, yet the distribution of ETEC virulence factors across age groups remains understudied. This study investigated the differential pathogenic profiles ETEC across various age groups, emphasizing the importance of selecting potential ETEC antigens tailored to infection patterns in infants and adults in Bangladesh.
Methods: This study utilized the icddr,b's 2% systematic hospital surveillance data of diarrheal patients ( = 14,515) from 2017 to 2022 to examine the age-specific pathogenesis and clinical manifestations of ETEC infections.
BMC Pediatr
December 2024
Department of Statistics and Data Science, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh.
Background: Immunization is the process of administering a vaccine to stimulate the development of immunity against an infectious agent, with the primary goal of preventing the illness that the infection causes. The authors aim to examine determinants of vaccination coverage among Somali children.
Methods: The authors used secondary data from the Somali Demographic Health Survey (SDHS)-2020.
PLoS One
December 2024
The Childhood Acute Illness and Nutrition (CHAIN) Network, Nairobi, Kenya.
Background: Severe acute malnutrition (SAM) constitutes a substantial burden in African hospitals. Despite adhering to international guidelines, high inpatient mortality rates persist and the underlying contributing factors remain poorly understood.
Objective: We evaluated the 10-year trend (2011-2021) in clinical factors and outcomes among children with severe wasting and/or nutritional edema at Malawi's largest nutritional rehabilitation unit (NRU).
Decreased vaccine coverage and waning immunity are cited as factors.
View Article and Find Full Text PDFJ Med Virol
December 2024
Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Despite the availability of a highly efficacious vaccine, a global resurgence of measles infections has occurred, largely due to decreased vaccination coverage and waning immunity following the two-dose vaccination schedule. This study aims to assess the cellular immune response in individuals who did not respond to the two-dose MMR vaccine and evaluate the efficacy and durability of immune responses after booster doses. An observational study was conducted involving 24 individuals who were seronegative for measles years after completing the two-dose MMR vaccine schedule.
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