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Blackcurrant (Ribes nigrum L.) and Its Association with Donepezil Restore Cognitive Impairment, Suppress Oxidative Stress and Pro-inflammatory Responses, and Improve Purinergic Signaling in a Scopolamine-Induced Amnesia Model in Mice.
Neurochem Res
January 2025
Department of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.
Purinergic signaling plays a major role in aging and neurodegenerative diseases, which are associated with memory decline. Blackcurrant (BC), an anthocyanin-rich berry, is renowned for its antioxidant and neuroprotective activities. However, evidence on the effects of BC on purinergic signaling is lacking.
View Article and Find Full Text PDFLignans from Schisandra chinensis (Turcz.) Baill ameliorates cognitive impairment in Alzheimer's disease and alleviates ferroptosis by activating the Nrf2/FPN1 signaling pathway and regulating iron levels.
J Ethnopharmacol
January 2025
Heilongjiang University of Chinese Medicine, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education Heilongjiang Touyan Innovation Team Program, Harbin 150040, People's Republic of China. Electronic address:
Ethnopharmacological Relevance: Schisandra chinensis (Turcz.) Baill (S. chinensis), first recorded in Shennong's Classic of the Materia Medica, is described as a "top grade medicine".
View Article and Find Full Text PDFNeuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia.
Alzheimers Res Ther
January 2025
Laboratory for Clinical Neuroscience, Center for Biomedical Technology, Universidad Politécnica de Madrid, IdISSC, Crta M40, km38, Madrid, 28223, Spain.
Background: Dementia patients commonly present multiple neuropathologies, worsening cognitive function, yet structural neuroimaging signatures of dementia have not been positioned in the context of combined pathology. In this study, we implemented an MRI voxel-based approach to explore combined and independent effects of dementia pathologies on grey and white matter structural changes.
Methods: In 91 amnestic dementia patients with post-mortem brain donation, grey matter density and white matter hyperintensity (WMH) burdens were obtained from pre-mortem MRI and analyzed in relation to Alzheimer's, vascular, Lewy body, TDP-43, and hippocampal sclerosis (HS) pathologies.
Prefrontally mediated inhibition of memory systems in dissociative amnesia.
Psychol Med
January 2025
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Background: The mechanisms underlying generalized forms of dissociative ('psychogenic') amnesia are poorly understood. One theory suggests that memory retrieval is inhibited via prefrontal control. Findings from cognitive neuroscience offer a candidate mechanism for this proposed retrieval inhibition.
View Article and Find Full Text PDF(A.ST. Hil.) Saff.: Neuroprotective Effect on Chemically Induced Amnesia, Anxiolytic Effects and Preclinical Safety Evaluation in Mice.
Biology (Basel)
November 2024
College of Health Science, Federal University of Grande Dourados, Dourados 79804-970, MS, Brazil.
, "araticum-seco", is known to contain several bioactive compounds that can mitigate oxidative stress and act on the central nervous system (CNS). This effect is partly attributed to its potent antioxidant and acetylcholinesterase (AChE) inhibitors. In this study, the effects were explored of the methanolic extract (MEDF) and alkaloid fraction (AFDF) of (leaves) on cognitive behaviors in male mice with scopolamine (Scop)-induced cognitive impairment and biochemical parameters.
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