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Filename: drivers/Session_files_driver.php
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Function: _error_handler
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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
Line: 249
Function: _error_handler
File: /var/www/html/index.php
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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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Filename: models/Detail_model.php
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Function: insertAPISummary
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Filename: helpers/my_audit_helper.php
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File: /var/www/html/application/helpers/my_audit_helper.php
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Function: formatAIDetailSummary
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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The Omega class of glutathione transferases (GSTs) forms a distinct class within the cytosolic GST superfamily because most of them possess a catalytic cysteine residue. The human GST Omega 1 isoform was first characterized twenty years ago, but it took years of work to clarify the roles of the human isoforms. Concerning the kingdom of fungi, little is known about the cellular functions of Omega glutathione transferases (GSTOs), although they are widely represented in some of these organisms. In this study, we re-assess the phylogeny and the classification of GSTOs based on 240 genomes of mushroom-forming fungi (Agaricomycetes). We observe that the number of GSTOs is not only extended in the order of Polyporales but also in other orders such as Boletales. Our analysis leads to a new classification in which the fungal GSTOs are divided into two Types A and B. The catalytic residue of Type-A is either cysteine or serine, while that of Type-B is cysteine. The present study focuses on Trametes versicolor GSTO isoforms that possess a catalytic cysteine residue. Transcriptomic data show that Type-A GSTOs are constitutive enzymes while Type-B are inducible ones. The crystallographic analysis reveals substantial structural differences between the two types while they have similar biochemical profiles in the tested conditions. Additionally, these enzymes have the ability to bind antioxidant molecules such as wood polyphenols in two possible binding sites as observed from X-ray structures. The multiplication of GSTOs could allow fungal organisms to adapt more easily to new environments.
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http://dx.doi.org/10.1016/j.fgb.2020.103506 | DOI Listing |
Wei Sheng Yan Jiu
November 2024
Shanghai University of Medicine & Health Sciences, Shanghai 200237, China.
Objective: To investigate the protective effect of lycopene on lung oxidative damage induced by atmospheric fine particulate matter(PM_(2.5)) in rats.
Methods: Sixty 7-week-old male Sprague-Dawley rats were randomly divided into six groups: normal control group, PM_(2.
Plant Physiol Biochem
December 2024
Department of Pomology, Faculty of Agriculture, Assiut University, Assiut, 71526, Egypt; Biology Research & Studies Institute, Assiut University, Assiut, 71526, Egypt. Electronic address:
Smart nanohybrid technology with potential advantages to plants has recently been developed formanaging the widespread pollution of heavy metals. Herein, we disclose a novel strategy to combat Pb stress in strawberry (Fragaria spp. cv.
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December 2024
Department of Zoology, School of Sciences, IFTM University, Moradabad, Uttar Pradesh, India.
The effect of EMS at final concentration of 0.09, 0.18, 0.
View Article and Find Full Text PDFFront Genet
December 2024
College of Agronomy, Qingdao Agricultural University, Qingdao, China.
Drought is a persistent and serious threat to crop yield and quality. The identification and functional characterization of drought tolerance-related genes is thus vital for efforts to support the genetic improvement of drought-tolerant crops. Barley is highly adaptable and renowned for its robust stress resistance, making it an ideal subject for efforts to explore genes related to drought tolerance.
View Article and Find Full Text PDFBMC Genomics
December 2024
Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Foshan University, Foshan, 528225, P.R. China.
Castration is widely used in poultry and livestock to enhance fat metabolism and improve the flavor, tenderness and juiciness of meat. However, the genetic regulatory mechanism underlying castration consequences have not been clarified. To investigate the key metabolites affecting the quality of capons and the key regulatory mechanisms, Qingyuan partridge roosters were subjected to castration.
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