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Recent Advances in Peptide Drug Discovery: Novel Strategies and Targeted Protein Degradation.
Pharmaceutics
November 2024
VIB-KU Leuven Center for Cancer Biology (VIB), 3000 Leuven, Belgium.
Recent technological advancements, including computer-assisted drug discovery, gene-editing techniques, and high-throughput screening approaches, have greatly expanded the palette of methods for the discovery of peptides available to researchers. These emerging strategies, driven by recent advances in bioinformatics and multi-omics, have significantly improved the efficiency of peptide drug discovery when compared with traditional in vitro and in vivo methods, cutting costs and improving their reliability. An added benefit of peptide-based drugs is the ability to precisely target protein-protein interactions, which are normally a particularly challenging aspect of drug discovery.
View Article and Find Full Text PDFThe Pfam protein families database: embracing AI/ML.
Nucleic Acids Res
January 2025
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
The Pfam protein families database is a comprehensive collection of protein domains and families used for genome annotation and protein structure and function analysis (https://www.ebi.ac.
View Article and Find Full Text PDFIdentification of phosphorylated small ORF-encoded peptides in Hep3B cells by LC/MS/MS.
J Proteomics
July 2024
School of Life Sciences, and Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, Hubei 430079, People's Republic of China. Electronic address:
Small ORF-encoded peptides (SEPs) are a class of low molecular weight proteins and peptides comprising <100 amino acids with important functions in various life activities. Although the sequence length is short, SEPs might also have post-translational modification (PTM). Phosphorylation is one of the most essential PTMs of proteins.
View Article and Find Full Text PDFIdentification of proteoforms of short open reading frame-encoded peptides in under different cultivation conditions.
Microbiol Spectr
December 2023
Systematic Proteome Research & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
The identification of short open reading frame-encoded peptides (SEP) and different proteoforms in single cultures of gut microbes offers new insights into a largely neglected part of the microbial proteome landscape. This is of particular importance as SEP provide various predicted functions, such as acting as antimicrobial peptides, maintaining cell homeostasis under stress conditions, or even contributing to the virulence pattern. They are, thus, taking a poorly understood role in structure and function of microbial networks in the human body.
View Article and Find Full Text PDFThe emerging functions of mini zinc finger (MIF) microproteins in seed plants: A minireview.
Biochimie
March 2024
UMR DIADE, Université de Montpellier, IRD, 911 Avenue Agropolis, 34394, cedex 5, Montpellier, France. Electronic address:
Mini zinc fingers constitute a class of microproteins that appeared early in evolution and expanded in seeds plants. In this review, the phylogenetic history, the functions and the mode of action of Mini zinc fingers in plants are reported and discussed. It appears that mini zinc fingers play an important role in the control of plant development.
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