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Leveraging a comprehensive unbiased RNAseq database to characterize human monocyte-derived macrophage gene expression profiles within commonly employed in vitro polarization methods.
Sci Rep
November 2024
Curriculum in Toxicology & Environmental Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Macrophages are pivotal innate immune cells which exhibit high phenotypic plasticity and can exist in different polarization states dependent on exposure to external stimuli. Numerous methods have been employed to simulate macrophage polarization states to test their function in vitro. However, limited research has explored whether these polarization methods yield comparable populations beyond key gene, cytokine, and cell surface marker expression.
View Article and Find Full Text PDFVitamin D reduces the expression of M1 and M2 macrophage markers in breast cancer patients.
Sci Rep
September 2024
Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Vitamin D (VD) is known for its immunomodulatory and anticancer effects. This study aimed to characterize tumor-associated macrophages (TAMs) in breast cancer (BC) and assess the influence of VD and its active metabolite, calcitriol, on their polarization. TAMs were isolated from BC patients and characterized.
View Article and Find Full Text PDFThe Contribution of Macrophage Plasticity to Inflammatory Arthritis and Their Potential as Therapeutic Targets.
Cells
September 2024
School of Biotechnology, Dublin City University, D09 V209 Dublin, Ireland.
Article Synopsis
- Inflammatory arthritis is a chronic autoimmune disease causing joint inflammation, loss of function, and significant comorbidities, with only 20% of patients achieving drug-free remission for over two years.
- Macrophages are crucial in inflammation; M1 macrophages promote inflammation and joint degradation, while M2 macrophages aid in healing and resolving inflammation, with various subtypes of M2 macrophages identified.
- Current treatments do not specifically target macrophages, but research is focused on repolarizing pro-inflammatory M1 macrophages to anti-inflammatory M2 types as a potential therapeutic strategy, highlighting the need to understand macrophage plasticity for effective new treatments.
EBV-associated epithelial cancers cells promote vasculogenic mimicry formation via a secretory cross-talk with the immune microenvironment.
Theranostics
September 2024
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, P. R. China.
Vasculogenic mimicry (VM) induced by Epstein-Barr virus (EBV) infection plays an important role in resistance to anti-vascular endothelial growth factor (VEGF) therapy in EBV-associated epithelial cancers; however, the interaction between VM and the immune microenvironment has not been systematically investigated. IHC and multiplex IHC analysis the relationships among tumour-associated macrophage (TAM), VM and EBV infection in EBV-associated epithelial cancer biopsies. and evidence using CRISPR-Cas9 system engineered EBV-infected epithelial cancer cells and mouse models support functional role and mechanism for M2c-like macrophages in the VM formation.
View Article and Find Full Text PDFOcotillol-Type Pseudoginsenoside-F11 Alleviates Lipopolysaccharide-Induced Acute Kidney Injury through Regulation of Macrophage Function by Suppressing the NF-κB/NLRP3/IL-1β Signaling Pathway.
J Agric Food Chem
September 2024
Innovation Center of New Drug Preclinical Pharmacology Evaluation of Jilin Province, Department of pharmacology, College of Basic Medicine of Jilin University, Changchun, Jilin 130012, China.
Acute kidney injury (AKI) is characterized by a sudden decline in renal function. The inflammatory response is the fundamental pathologic alteration throughout AKI, regardless of the various causal factors. Macrophages are the main immune cells involved in the inflammatory microenvironment in AKI.
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