Photonic quantum memory is the core element in quantum information processing (QIP). For the scalable and convenient practical applications, great efforts have been devoted to the integrated quantum memory based on various waveguides fabricated in solids. However, on-demand storage of qubits, which is an essential requirement for QIP, is still challenging to be implemented using such integrated quantum memory. Here we report the on-demand storage of time-bin qubits in an on-chip waveguide memory fabricated on the surface of a ^{151}Eu^{3+}:Y_{2}SiO_{5} crystal, utilizing the Stark-modulated atomic frequency comb protocol. A qubit storage fidelity of 99.3%±0.2% is obtained with single-photon-level coherent pulses, far beyond the highest fidelity achievable using the classical measure-and-prepare strategy. The developed integrated quantum memory with the on-demand retrieval capability represents an important step toward practical applications of integrated quantum nodes in quantum networks.
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http://dx.doi.org/10.1103/PhysRevLett.125.260504 | DOI Listing |
J Immunother Cancer
January 2025
Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.
Materials And Methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.
Talanta
January 2025
Pharmaceutical Chemistry Research Laboratory I, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India. Electronic address:
The cholinergic deficits and amyloid beta (Aβ) aggregation are the mainstream simultaneously observed pathologies during the progression of Alzheimer's disease (AD). Deposited Aβ plaques are considered to be the primary pathological hallmarks of AD and are contemplated as promising diagnostic biomarker. Herein, a series of novel theranostic agents were designed, synthesised and evaluated against cholinesterase (ChEs) enzymes and detection of Aβ species, which are major targets for development of therapeutics for AD.
View Article and Find Full Text PDFPhilos Trans A Math Phys Eng Sci
January 2025
Institute for Solid State Physics, Friedrich Schiller University Jena, Jena, Germany.
Memristive technology mitigates the memory wall issue in von Neumann architectures by enabling in-memory data processing. Unlike traditional complementary metal-oxide semiconductor (CMOS) technology, memristors provide a new paradigm for implementing cryptographic functions and security considerations. While prior research explores memristors for cryptographic functions and side-channel attack vulnerabilities, our study uniquely addresses memristor-oriented countermeasures.
View Article and Find Full Text PDFPhilos Trans A Math Phys Eng Sci
January 2025
Peter Gruenberg Institut (PGI-7), Forschungszentrum Juelich GmbH, Juelich, Germany.
The thirst for more efficient computational paradigms has reignited interest in computation in memory (CIM), a burgeoning topic that pivots on the strengths of more versatile logic systems. Surging ahead in this innovative milieu, multi-valued logic systems have been identified as possessing the potential to amplify storage density and computation efficacy. Notably, ternary logic has attracted widespread research owing to its relatively lower computational and storage complexity, offering a promising alternative to the traditional binary logic computation.
View Article and Find Full Text PDFLiNbO domain structures have been widely applied in nonlinear beam shaping, quantum light generation, and nonvolatile ferroelectric memory. The recent developments in nanoscale domain engineering techniques make it possible to fabricate sub-diffracted nanodomains in LiNbO crystal for high-speed modulation and high-capacity storage. However, it still lacks a feasible and efficient way to characterize these nanoscale domains.
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