Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC mice survived DSS-induced colitis, MSC mice showed elevated pro-inflammatory cytokines with severer pathology, reduced body weight, and earlier death. Reversal of colitis symptoms in MSC mice by IL-22 antagonism suggests the existence of MSC:IL-22 regulatory axis.
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