Background: Patients with multiple sclerosis (MS) often experience high levels of anxiety, specifically about the (unpredictable) future related to MS. Worries about physical and cognitive declines can cause frightening mental representations of future 'worst-case scenarios'. Evidence of the applicability of eye movement desensitization reprocessing (EMDR) using flash-forward on anxiety is growing.
Objective: This pilot study examines the flash-forward EMDR procedure as a treatment option in MS patients suffering from anxiety specifically related to future MS problems.
Methods: Eight MSpatients suffering from anxiety were treated with one to three sessions of EMDR with a flash-forward target. Treatment effects were evaluated with the use of questionnaires on anxiety, depression, worry, cognitive avoidance, and quality of life at three time points: pre-treatment, direct post-treatment, and three-month follow-up.
Results: Significant improvement was shown post-treatment compared to pre-treatment on anxiety, depression, and worry. In a case series analysis, all but one participant showed a clinically important difference in anxiety.
Conclusion: Before implementation on a larger scale can be recommended, the value of EMDR with flash forward targets for anxiety in MS need to be further examined. However, the positive results on this pilot can be seen as promising and motivation for future studies.
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http://dx.doi.org/10.1177/2055217320974388 | DOI Listing |
Front Biosci (Landmark Ed)
January 2025
Division of Molecular Psychiatry, Center of Mental Health, University of Hospital Würzburg, 97080 Würzburg, Germany.
Background: The inheritance of the short allele, encoding the serotonin transporter (SERT) in humans, increases susceptibility to neuropsychiatric and metabolic disorders, with aging and female sex further exacerbating these conditions. Both central and peripheral mechanisms of the compromised serotonin (5-HT) system play crucial roles in this context. Previous studies on SERT-deficient (Sert) mice, which model human SERT deficiency, have demonstrated emotional and metabolic disturbances, exacerbated by exposure to a high-fat Western diet (WD).
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
January 2025
HUN-REN-SZTE Neuroscience Research Group, Hungarian Research Network, University of Szeged (HUN-REN-SZTE), Danube Neuroscience Research Laboratory, H-6725 Szeged, Hungary.
Backgrounds: Memory and emotion are especially vulnerable to psychiatric disorders such as post-traumatic stress disorder (PTSD), which is linked to disruptions in serotonin (5-HT) metabolism. Over 90% of the 5-HT precursor tryptophan (Trp) is metabolized via the Trp-kynurenine (KYN) metabolic pathway, which generates a variety of bioactive molecules. Dysregulation of KYN metabolism, particularly low levels of kynurenic acid (KYNA), appears to be linked to neuropsychiatric disorders.
View Article and Find Full Text PDFSubst Use Misuse
January 2025
Defense Personnel and Security Research Center, Peraton, Seaside, California, USA.
Background: This study investigated relationships between low-income adolescent drinkers' frequent alcohol use and five factors: social disorganization, social structural, social integration, mental health, and access to healthcare.
Objective: A sample of 1,256 low-income adolescent drinkers and caregivers were extracted from the Future of Families and Child Wellbeing Study.
Results: Logistic regression yielded results showing adolescent drinkers' weekly drinking to be associated positively with Hispanic adolescents, drinking peers, adolescents' depression/anxiety, and caregiver's daily drinking.
J Oral Rehabil
January 2025
Departamento de Odontologia Restauradora, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Background: Previous research has highlighted the multifactorial nature of awake bruxism (AB), including its associations with stress, anxiety and other psychological factors. Dispositional mindfulness, known for its benefits in enhancing emotional regulation and reducing stress, has not yet been thoroughly investigated in association with AB.
Objective: This study aimed to investigate whether levels of dispositional mindfulness predict the efficacy of ecological momentary intervention (EMI) in reducing the frequency of AB behaviours.
Clin Exp Allergy
January 2025
Division of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, SAR, China.
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