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Pharmacological resynchronisation with flecainide in an infant with Ebstein anomaly and Wolff-Parkinson-White pattern: a case report.
Eur Heart J Case Rep
September 2024
The Heart Centre for Children, The Children's Hospital at Westmead, Corner Hawkesbury Road and Hainsworth St, Westmead, NSW 2145, Australia.
Article Synopsis
- - An infant diagnosed with Ebstein anomaly experienced severe left ventricular dysfunction and was found to have a right-sided accessory pathway contributing to this issue.
- - Treatment with the antiarrhythmic drug flecainide effectively blocked the abnormal conduction, leading to improvements in heart function and a reduction in left ventricular size.
- - The case highlights the potential benefits of using flecainide in patients with Ebstein anomaly and associated conduction abnormalities, especially when other interventions are not viable.
Comparison Between Histidine-Tryptophan-Ketoglutarate Cardioplegia and Cold Blood Cardioplegia for Myocardial Protection in Tetralogy of Fallot Patients Undergoing Surgical Repair: A Randomized Clinical Trial.
J Cardiothorac Vasc Anesth
November 2024
Department of Anaesthesiology, Intensive Care, and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Article Synopsis
- This study aimed to compare the effectiveness of histidine-tryptophan-ketoglutarate (HTK) cardioplegia and cold blood cardioplegia (CBC) on postoperative right ventricular function in children undergoing tetralogy of Fallot repair.
- A total of 100 children aged 1 to 5 years were randomly assigned to receive either HTK or CBC, and various heart function metrics were measured post-surgery.
- Results showed that the HTK group experienced better early cardiac function and lower troponin levels, suggesting it provides superior cardiac protection compared to CBC in these patients.
The Application of Mesenchymal Stem Cells in Different Cardiovascular Disorders: Ways of Administration, and the Effectors.
Stem Cell Rev Rep
October 2024
Physiology, Department of Basic Medical Sciences, Medicine Faculty, Selcuk University, Konya, Türkiye.
The heart is an organ with a low ability to renew and repair itself. MSCs have cell surface markers such as CD45, CD34, CD31, CD4, CD11a, CD11b, CD15, CD18, CD25, CD49d, CD50, CD105, CD73, CD90, CD9, CD10, CD106, CD109, CD127, CD120a, CD120b, CD124, CD126, CD140a, CD140b, adherent properties and the ability to differentiate into cells such as adipocytes, osteoblasts and chondrocytes. Autogenic, allogeneic, normal, pretreated and genetically modified MSCs and secretomes are used in preclinical and clinical studies.
View Article and Find Full Text PDFA Novel Diastolic Doppler Index Less Affected by Aortic Arch Anomalies Co-existing with Coarctation.
Pediatr Cardiol
July 2024
Department of Biomedical Engineering, Marquette University and the Medical College of Wisconsin, Milwaukee, WI, USA.
Severity assessment for coarctation of the aorta (CoA) is challenging due to concomitant morphological anomalies (complex CoA) and inaccurate Doppler-based indices. Promising diagnostic performance has been reported for the continuous flow pressure gradient (CFPG), but it has not been studied in complex CoA. Our objective was to characterize the effect of complex CoA and associated hemodynamics on CFPG in a clinical cohort.
View Article and Find Full Text PDFThe American Association for Thoracic Surgery (AATS) 2024 expert consensus document: Management of neonates and infants with Ebstein anomaly.
J Thorac Cardiovasc Surg
August 2024
Cardiothoracic Unit, Great Ormond Street Hospital, London, United Kingdom.
Article Synopsis
- - The American Association for Thoracic Surgery assembled a committee of experts to create guidelines for managing symptomatic neonates and infants with Ebstein anomaly (EA), focusing on risk assessment and treatment strategies.
- - A quantitative review was conducted, identifying 71 relevant studies on neonates and infants with EA, leading to the creation of expert consensus statements through a voting process among medical professionals.
- - Key findings suggest certain high-risk features (like severe cardiomegaly and pulmonary valve atresia) in EA patients warrant urgent intervention, while more stable neonates can be monitored for potential recovery.
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