Correlation between contrast enhanced plaques and plaque diffusion restriction and their signal intensities in FLAIR images in patients who admitted with acute symptoms of multiple sclerosis.

Introduction: One of the most common demyelinating disorders is Multiple Sclerosis (MS), which can lead to extensive disability in patients. Appearance of active lesions can be an important sign of disease development. The correlation between the restriction of DWI signal, contrast-enhancement, and demyelinated plaque's signals were evaluated in this study.

Material And Method: 34 MS patients with 1043 MS-plaques who had acute attacks took part in this study. Three MRI pulse-sequences, FLAIR, DWI, and post-contrast enhanced T1 weighted, were compared. Using the signal intensity of MS-lesions and normal brain tissue in FLAIR images, lesion/noise ratio (LNR) and lesion/white-matter ratio (LWR) were calculated. Sensitivity and specificity of LNR and LWR were estimated to determine a cut off value.

Results: 7.86% of MS-plaques were enhanced in T1 contrast-enhanced MRI. 2.4% showed DWI restriction. 0.77% showed both diffusion-restriction and T1 contrast-enhancement, 1.63% indicated diffusion-restriction but no contrast-enhancement and 7.09% showed contrast-enhancement but no diffusion-restriction. Among diffusion-restricted plaques, 32% were enhanced in T1-weighted post-contrast enhanced images and it should be noted that diffusion-restriction was seen in 9.76% of enhanced plaques. The sensitivity and specificity of the DWI restriction and its effectiveness in detecting active-plaques were calculated as 12.31% and 98.26%, respectively. The accuracy of this method in detecting the active MS-plaques estimated as 92.91%. The cut-off value for LWR and LNR was between 0.9-1 and 24-28.

Conclusion: By calculating LNR and LWR, the FLAIR images can be evaluated to detect new MS-plaques. LWR had higher sensitivity and specificity in comparison to LNR so it is a better index in the detection of active-plaques. Although post contrast T1 is the gold standard for evaluating active plaques, in the case of a contraindication to gadolinium, DWI can offer supplemental information on the diffusion restriction of MS plaques in a non-contrast protocol.