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Evaluation of biofilm formation and antimicrobial susceptibility (drug resistance) of Candida albicans isolates.
Braz J Microbiol
November 2024
Department of Microbiology, Annamalai University, Annamalai Nagar, Chidambaram, Tamilnadu, 608002, India.
Candida albicans comprises over 80% of isolates from all forms of human candidiasis. Biofilm formation enhances their capacity to withstand therapeutic treatments. In addition to providing protection, biofilm formation by C.
View Article and Find Full Text PDFSystemic absorption and safety of topical terbinafine hydrochloride 10% solution (MOB015B): a phase 1 maximal usage trial in patients with moderate-to-severe onychomycosis.
Antimicrob Agents Chemother
October 2024
Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Unlabelled: Topical antifungals may be considered to treat onychomycosis with minimal risk of systemic side effects. In this study, we assess the safety, tolerability, systemic exposure, and pharmacokinetic characteristics of topical terbinafine hydrochloride 10% solution (MOB015B) in adults with moderate-to-severe onychomycosis. Clinically and mycologically confirmed patients with toenail onychomycosis ( = 20) were enrolled in this single-center, open-label study .
View Article and Find Full Text PDFChromoblastomycosis caused by , concurrent with myiasis, in a recipient of a kidney transplant: a compelling case report.
Front Med (Lausanne)
July 2024
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- * A case study highlights a 46-year-old woman with chromoblastomycosis, confirming the diagnosis through skin examinations and fungal cultures, while also revealing co-infestation by fly larvae.
- * The patient was successfully treated with voriconazole and terbinafine, highlighting the need for awareness and understanding of chromoblastomycosis in occupationally exposed individuals in affected regions.
Subacute Cutaneous Lupus Erythematosus Secondary to Intravenous Immunoglobulin Infusions.
Cureus
June 2024
Dermatology, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
Article Synopsis
- * Its causes are not fully understood but may involve genetics, environmental factors, and immune system issues; certain medications can also trigger SCLE, such as calcium channel blockers and diuretics.
- * A case is highlighted where SCLE developed in a patient receiving intravenous immunoglobulin (IVIG) for another condition, suggesting that healthcare providers across specialties should be aware of this potential side effect.
An update on antifungal resistance in dermatophytosis.
Expert Opin Pharmacother
April 2024
Mediprobe Research Inc, London, Ontario, Canada.
Introduction: The reports of resistance to antifungal agents used for treating onychomycosis and other superficial fungal infections are increasing. This rise in antifungal resistance poses a public health challenge that requires attention.
Areas Covered: This review explores the prevalence of dermatophytes and the current relationship between dermatophyte species, their minimum inhibitory concentrations (MICs) for terbinafine (an allylamine) and itraconazole (an azole), and various mutations prevalent in these species.
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