On-Demand Cascade Release of Hydrophobic Chemotherapeutics from a Multicomponent Hydrogel System.

ACS Biomater Sci Eng

Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.

Published: May 2018

A multicomponent hydrogel drug-delivery platform with covalent incorporation of core-cross-linked star (CCS) polymers has been fabricated through dual cross-linking reactions. The presence of amphiphilic CCS polymers enhances the mechanical stability of the network and allows for immobilization of hydrophobic chemotherapeutics (e.g., doxorubicin: DOX) within a hydrophilic matrix. Thanks to thiol-responsive disulfide segments, the hybrid network is selectively degradable upon exposure to the glutathione-rich tumor environment, leading to an on-demand cascade release of payloads in a prolonged manner. After network degradation, the integrity of the therapeutic cargos is still well-protected by the CCS polymeric carriers. A cellular study demonstrated efficient internalization of released drug-containing CCS polymers by HeLa cells, intracellular delivery of encapsulated drugs following pH-mediated erosion of the CCS containers, and excellent cytocompatibility of this hydrogel system.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsbiomaterials.8b00166DOI Listing

Publication Analysis

Top Keywords

ccs polymers
12
on-demand cascade
8
cascade release
8
hydrophobic chemotherapeutics
8
multicomponent hydrogel
8
hydrogel system
8
ccs
5
release hydrophobic
4
chemotherapeutics multicomponent
4
system multicomponent
4

Similar Publications

Ferroptosis, a non-apoptotic form of cell death characterized by the production of reactive oxygen species (ROS) and massive accumulation of lipid peroxidation (LPO), shows significant promise in cancer therapy. However, the overexpression of glutathione (GSH) at the tumor site and insufficient ROS often result in unsatisfactory therapeutic efficacy. A multistage, GSH-consuming, and ROS-providing carrier-free nanodrug capable of efficiently loading copper ions (Cu), sorafenib (SRF), and chlorogenic acid (CGA) (Cu-CGA-SRF, CCS-NDs) is developed to mediate enhanced ferroptosis therapy.

View Article and Find Full Text PDF

Distinct roles of centriole distal appendage proteins in ciliary assembly and disassembly.

Cell Commun Signal

December 2024

Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.

The primary cilium is a cellular organelle whose assembly and disassembly are closely linked to the cell cycle. The centriole distal appendage (DA) is essential for the early stages of ciliogenesis by anchoring the mother centriole to the cell surface. Despite the identification of over twelve proteins constituting the DA, including CEP83, CEP89, CEP164, FBF1, and SCLT1, their specific functions in ciliary dynamics are not fully understood.

View Article and Find Full Text PDF

Macrofouling on marine litter in a Southwest Atlantic urban tropical bay and surrounds.

Mar Pollut Bull

December 2024

Programa de Pós-Graduação em Dinâmica dos Oceanos e da Terra, Universidade Federal Fluminense (UFF) Vermelha-Gragoatá, Niteroi, RJ 24210, Brazil; Departamento de Biologia Marinha, Universidade Federal Fluminense, Niterói, Brazil; Laboratório de Ecologia de Sedimentos, Instituto de Biologia, Universidade Federal Fluminense, R. Prof. Marcos Waldemar de Freitas Reis - São Domingos, Niterói, RJ 24210-201, Brazil.

Rafting is the transport of marine litter by organisms, influenced by substrate characteristics such as degradation, shape, surface orientation, color, and polymer type. This study focuses on rafting in the Southwest Atlantic, characterizing biofouling on different materials across high- and low-energy beaches. Conducted in Guanabara Bay and Niteroi's oceanic beaches, sampling focused on strandlines.

View Article and Find Full Text PDF

This study used target, suspect, and non-target screening, to assess the presence of per- and polyfluoroalkyl substances (PFASs) in domestic (municipal) and industrial wastewater treatment plants (WWTPs) in South Korea. Target analysis quantified 20 PFASs in the WWTP effluents. Total concentration of PFASs ranged from 69.

View Article and Find Full Text PDF

Microplastics are tiny plastic particles with a usual diameter ranging from ~ 1 μ to 5 µm. Recently, microplastic pollution has raised the attention of the worldwide environmental and human concerns. In human beings, digestive system illness, respiratory system disorders, sleep disturbances, obesity, diabetes, and even cancer have been reported after microplastic exposure either through food, air, or skin.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!