AI Article Synopsis
- A new hybrid nanogel system combining polypeptide-engineered gold nanorods has been created for targeted drug delivery and tumor therapy.
- The surface of gold nanorods is coated with a specific engineered polypeptide (PCA(RGD)), which allows for the self-assembly of a hydrogel that can carry the chemotherapy drug doxorubicin.
- This system enhances stability in saline environments, reduces toxicity, and improves drug uptake in cancer cells, showing promising potential for effective combined chemo-photothermal therapy against tumors.
Article Abstract
A new hybrid nanogel system using polypetide-engineered coated gold nanorods has been developed for targeted drug delivery and tumor chemo-photothermal therapy. A triblock engineered polypeptide PCA(RGD) was immobilized on the surface of gold nanorods by the electrostatic adsorption. The immobilized PCA(RGD) formed hydrogel by self-assembly to load doxorubicin for chemotherapy. Coating polypeptide-engineering hydrogel on gold nanorods enhanced the stability in high-salt media and significantly reduced the cytotoxicity. An arginine-glycine-aspartic acid motif was introduced into the polypeptide on the surface of hybrid nanogels to promote cellular uptake through receptor-mediated endocytosis in αβ overexpressing HeLa cells. In addition, compared with single chemotherapy and near-infrared photothermal therapy, the combination therapy has a synergistic effect on the cancer cells. Thus, the chemo-photothermal therapy based on polypeptide-engineered hydrogel coated gold nanorods and doxorubicin is expected to have great potential impact on cancer therapy.
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| http://dx.doi.org/10.1021/acsbiomaterials.7b00359 | DOI Listing |
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