AI Article Synopsis
- Overdiagnosed cancers are those found through screening that would not have caused symptoms in a patient’s lifetime, including indolent cancers.
- Competing cause of mortality (CCM) overdiagnosis occurs when patients die from other conditions and would have remained undiagnosed without screening, with some screen-detected cancers leading to deaths soon after detection.
- In the National Lung Screening Trial, few participants died from non-lung cancer causes shortly after being screened, suggesting less frequent CCM overdiagnosis in that trial compared to community-based screenings.
Article Abstract
Overdiagnosed cancers are those that are screen-detected but never would have been symptomatic during patients' lifetimes. Indolent cancers are overdiagnosed cancers. Non-indolent cancers can be overdiagnosed when patients die of causes other than the screen-detected cancer and would have, in the absence of screening, been asymptomatic and undiagnosed at the time of death. This is termed competing cause of mortality (CCM) overdiagnosis. Deaths soon after screen detection may represent CCM overdiagnosis. We examined time from screen-detection to death among the 35 participants in the National Lung Screening Trial (NLST) low-dose computed tomography arm with screen-detected lung cancer and died of non-lung-cancer causes. Seven participants died within 6 months, and 20 died more than 24 months after diagnosis. Deaths due to non-lung cancer causes soon after screen detection were uncommon, arguing against widespread CCM overdiagnosis in the NLST. However, CCM overdiagnosis is likely more frequent in community-based screening given the higher prevalence of comorbidities.
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| http://dx.doi.org/10.1016/j.lungcan.2020.12.031 | DOI Listing |
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