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Designing boron-doped carbon dot-functionalized COFs for fluorescence screening and liquid chromatography tandem mass spectrometry detection of toxins.
J Chromatogr A
January 2025
School of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China; Ningxia Key Laboratory of Solar Chemical Conversion Technology, North Minzu University, Yinchuan, 750021, China; Key Laboratory for Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021, China. Electronic address:
In recent years, mushroom poisoning has been one of the most important factors of food poisoning in China, timely identification of the toxins contained in mushrooms is crucial for the treatment of patients. In this study, boric acid carbon dots (BA-CDs) can undergo specific boron affinity reactions with amatoxins toxins containing o-dihydroxyl groups by means of boric acid groups. Functional covalent organic framework (COF) and BA-CDs were combined to design a adsorbent with boric acid group (COF@VBC@BA-CDs) was designed to meet the requirements of both fluorescent and pretreated materials for amatoxins.
View Article and Find Full Text PDFDetection and quantification of Amatoxin in wild mushrooms from North-East India using HPLC-PDA method for food safety purposes.
Toxicon
November 2024
Department of Botany, Mizoram University, Tanhril, Aizawl, Mizoram, 796004, India. Electronic address:
Article Synopsis
- * The study used HPLC-PDA to identify and measure α-amanitin, a highly toxic compound found in specific wild mushrooms, confirming its presence in Amanita virosa and Amanita bisporigera.
- * Findings indicate that the detection method is precise and reliable, with successful quantification of α-amanitin in wild samples, emphasizing the need for better safety measures to prevent mushroom poisoning.
An outbreak of -like (Galerina cf. sulciceps) mushroom poisoning.
Clin Toxicol (Phila)
November 2024
Department of Nephrology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Article Synopsis
- A group of people in China got sick after accidentally eating poisonous mushrooms that contain dangerous toxins called amatoxins.
- The study looked at 15 patients who had symptoms like nausea, vomiting, and diarrhea, and many of them also had liver problems.
- Researchers think these mushrooms might be a new type similar to another kind, but they need to do more studies to be sure.
Rapid analysis of amatoxins in human urine by means of affinity column chromatography and liquid chromatography-high-resolution tandem mass spectrometry.
Sci Rep
September 2024
Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Kirrberger Str., Building 46, 66421, Homburg, Germany.
Article Synopsis
- Amatoxins, which are cyclic peptides, are responsible for a significant number of fatalities each year, making their analysis crucial for public health.
- The study introduces a novel analytical method using affinity column chromatography with a specific monoclonal antibody and high-resolution mass spectrometry to detect low levels of amatoxins in human urine samples, achieving a sensitivity of 1 ng/mL.
- The new procedure has been validated for specific amatoxins and can determine acute intoxications within 90 minutes, suggesting that similar techniques could be applied to analyze other toxic peptides effectively.
Toxicokinetics of α- and β-amanitin in mice following single and combined administrations: Simulating in vivo amatoxins processes in clinical cases.
Toxicon
August 2024
Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences, Ministry of Justice, Shanghai, 200063, PR China. Electronic address:
Article Synopsis
- The study investigated the toxicokinetics and tissue distribution of the highly toxic compounds α-amanitin and β-amanitin found in Amanita mushrooms by using a new ultra-performance liquid chromatography-mass spectrometry method in mice.
- Results showed both amatoxins had similar absorption rates and elimination half-lives, but α-amanitin reached lower peak concentrations compared to β-amanitin after oral administration.
- Tissue distribution indicated that both toxins were primarily found in the intestines and kidneys, with β-amanitin showing significantly higher concentrations in certain organs after administration, while both compounds were mainly excreted through feces.
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