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Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform. | LitMetric

Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform.

Angew Chem Int Ed Engl

Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600, MB, Eindhoven, The Netherlands.

Published: March 2021

Biological processes rely on transient interactions that govern assembly of biomolecules into higher order, multi-component systems. A synthetic platform for the dynamic assembly of multicomponent complexes would provide novel entries to study and modulate the assembly of artificial systems into higher order topologies. Here, we establish a hybrid DNA origami-based approach as an assembly platform that enables dynamic templating of supramolecular architectures. It entails the site-selective recruitment of supramolecular polymers to the platform with preservation of the intrinsic dynamics and reversibility of the assembly process. The composition of the supramolecular assembly on the platform can be tuned dynamically, allowing for monomer rearrangement and inclusion of molecular cargo. This work should aid the study of supramolecular structures in their native environment in real-time and incites new strategies for controlled multicomponent self-assembly of synthetic building blocks.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048573PMC
http://dx.doi.org/10.1002/anie.202016244DOI Listing

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