AI Article Synopsis
- The study investigates glycemic regression among adults with newly diagnosed diabetes and intermediate hyperglycemia, finding that while regression is common, it often appears more favorable than it is when adjusting for regression to the mean (RTM).
- Out of those with newly diagnosed diabetes, 49.4% showed partial or complete regression, but this dropped to 20.2% after accounting for RTM; similar reductions were noted for intermediate hyperglycemia, depending on the definition used.
- Weight loss of at least 2.6% significantly improved chances of regression for both diabetes and intermediate hyperglycemia, highlighting the role of lifestyle changes in managing these conditions over time.
Article Abstract
Objective: Glycemic regression is common in real-world settings, but the contribution of regression to the mean (RTM) has been little investigated. We aimed to estimate glycemic regression before and after adjusting for RTM in a free-living cohort of adults with newly ascertained diabetes and intermediate hyperglycemia (IH).
Research Design And Methods: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a cohort study of 15,105 adults screened between 2008 and 2010 with standardized oral glucose tolerance test and HbA, repeated after 3.84 ± 0.42 years. After excluding those receiving medical treatment for diabetes, we calculated partial or complete regression before and after adjusting baseline values for RTM.
Results: Regarding newly ascertained diabetes, partial or complete regression was seen in 49.4% (95% CI 45.2-53.7); after adjustment for RTM, in 20.2% (95% CI 12.1-28.3). Regarding IH, regression to normal levels was seen in 39.5% (95% CI 37.9-41.3) or in 23.7% (95% CI 22.6-24.3), depending on use of the World Health Organization (WHO) or the American Diabetes Association (ADA) definition, respectively; after adjustment, corresponding frequencies were 26.1% (95% CI 22.4-28.1) and 19.4% (95% CI 18.4-20.5). Adjustment for RTM reduced the number of cases detected at screening: 526 to 94 cases of diabetes, 3,118 to 1,986 cases of WHO-defined IH, and 6,182 to 5,711 cases of ADA-defined IH. Weight loss ≥2.6% was associated with greater regression from diabetes (relative risk 1.52, 95% CI 1.26-1.84) and IH (relative risk 1.30, 95% CI 1.17-1.45).
Conclusions: In this quasi-real-world setting, regression from diabetes at ∼4 years was common, less so for IH. Regression was frequently explained by RTM but, in part, also related to improved weight loss and homeostasis over the follow-up.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783938 | PMC |
| http://dx.doi.org/10.2337/dc20-2030 | DOI Listing |
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