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Is Adjunctive Hyperbaric Oxygen Treatment Alone or with Surgery the Proper Management for Active and Persistent Osteoradionecrosis? | LitMetric
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Is Adjunctive Hyperbaric Oxygen Treatment Alone or with Surgery the Proper Management for Active and Persistent Osteoradionecrosis?

Kamonwan Jenwitheesuk Ajanee Mahakkanukrauh Wiyada Punjaruk Patravoot Vatanasapt Kriangsak Jenwitheesuk Palakorn Surakunprapha Suthin Jinaporntham Krittinant Uraiwan Phasuk Limrattanapimpa

Adv Skin Wound Care

At Khon Kaen University, Khon Kaen, Thailand, Kamonwan Jenwitheesuk, MD, is Associate Professor, Plastic & Reconstructive Unit, Department of Surgery, Faculty of Medicine; Ajanee Mahakkanukrauh, MD, is Associate Professor, Division of Allergy-Immunology-Rheumatology, Faculty of Medicine; Wiyada Punjaruk, MD, PhD, is Assistant Professor, Department of Physiology, Faculty of Medicine; Patravoot Vatanasapt, MD, is Assistant Professor, Head & Neck Surgery Unit, Department of Otorhinolaryngology, Faculty of Medicine; Kriangsak Jenwitheesuk, MD, is Associate Professor, General Surgery Unit, Department of Surgery, Faculty of Medicine; Palakorn Surakunprapha, MD, is Assistant Professor, Plastic & Reconstructive Unit, Department of Surgery, Faculty of Medicine; Suthin Jinaporntham, MD, DDS, is Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry; Krittinant Uraiwan, DDS, is Maxillofacial Surgeon, Dental Department, Srinagarind Hospital, Faculty of Medicine; and Phasuk Limrattanapimpa, MNS, is Nurse Specialist, Hyperbaric Oxygen Therapy Unit, Srinagarind Hospital, Faculty of Medicine. Acknowledgments: The authors thank University of Wisconsin Professor Emeritus James A. Will for assistance with the English language presentation of the manuscript under the aegis of the Publication Clinic, Research Affairs, Faculty of Medicine, KKU. This study was funded by a grant from Khon Kaen University, Faculty of Medicine (no. MN61203). The authors have disclosed no other financial relationships related to this article. Submitted January 15, 2020; accepted in revised form March 4, 2020.

Published: February 2021

This study enrolled patients with stage 3 osteoradionecrosis. There were three treatment modalities: antibiotics, hyperbaric oxygen therapy (HBOT), and surgery. Complete healing was the primary outcome. Multiple logistic regression analysis demonstrated that surgery with HBOT improved wound healing better than HBOT alone.

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http://dx.doi.org/10.1097/01.ASW.0000725164.18431.a7DOI Listing

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