Rh-catalyzed sp C-H cross-coupling of acrylamides with organoboron reactants has been accomplished using a commercially available -2,6-difluoroaryl acrylamide auxiliary. A broad range of aryl and vinyl boronates as well as a variety of heterocyclic boronates with strong coordinating ability can serve as the coupling partners. This transformation proceeds under moderate reaction conditions with excellent functional group tolerance and high regioselectivity.
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| http://dx.doi.org/10.1021/acs.orglett.0c03688 | DOI Listing |
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