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Ag-Catalyzed ring-opening of tertiary cycloalkanols for C-H functionalization of cyclic aldimines. | LitMetric

Ag-Catalyzed ring-opening of tertiary cycloalkanols for C-H functionalization of cyclic aldimines.

Chem Commun (Camb)

Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, Henan 476000, China. and College of Chemistry, Zhengzhou University, Zhengzhou, Henan 450052, China.

Published: February 2021

We firstly describe a silver-catalyzed direct C-H functionalization of cyclic aldimines with cyclopropanols and cyclobutanols via a radical-mediated C-C bond cleavage strategy. The desired products were generated in decent yields with wide substrate scope under mild reaction conditions. In addition, a gram-scale reaction and synthetic transformation of the product were performed.

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Source
http://dx.doi.org/10.1039/d0cc07181aDOI Listing

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