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Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma. | LitMetric

AI Article Synopsis

  • * Results showed that eyes with more severe glaucoma had thinner macular ganglion cell complex (mGCC) and circumpapillary retinal nerve fiber layer (cpRNFL) and lower pfVD, linking pfVD declines to worsening visual field damage (MD).
  • * While macular vessel branching complexity wasn't correlated with visual field loss, it was found to be lower in patients with systemic hypertension, indicating other health factors may influence these measurements.

Article Abstract

The aim of this study was to investigate the relationship between glaucoma severity and perifoveal vessel density (pfVD), branching complexity, and foveal avascular zone (FAZ) size in normal tension glaucoma (NTG). 31 patients with NTG washed out of glaucoma medications were subjected to tests including; intraocular pressure measurement; standard automated perimetry; optical coherence tomography (OCT) measurement of macular ganglion cell complex (mGCC), inner macular thickness (IMT) and circumpapillary retinal nerve fibre layer (cpRNFL); and OCT angiography measurement of pfVD, FAZ perimeter and multispectral fractal dimensions (MSFD). Eyes with more severe glaucoma had significantly thinner mGCC and cpRNFL and lower pfVD. MD decreased by 0.4 dB (95% CI 0.1 to 0.6 dB, P = 0.007) for every 1% decrease in pfVD. Lower MSFD was observed in eyes with lower pfVD and in patients with systemic hypertension. Multivariable analysis, accounting for age and OCTA quality, found lower pfVD remained significantly associated with thinner IMT, thinner mGCC and worse MD but not with MSFD. pfVD was reduced in NTG and was diminished in eyes with worse MD. Macular vessel branching complexity was not related to severity of visual field loss but was lower in patients with systemic hypertension.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807020PMC
http://dx.doi.org/10.1038/s41598-020-80080-zDOI Listing

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