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Contribution of Magnetic Resonance Imaging Studies to the Understanding of Cerebral Malaria Pathogenesis.
Pathogens
November 2024
Centre de Résonance Magnétique Biologique et Médicale (CRMBM) UMR 7339, Faculté des Sciences Médicales et Paramédicales la Timone, Aix-Marseille Université, CNRS, 13055 Marseille, France.
Cerebral malaria (CM), the most lethal clinical syndrome of infection, mostly affects children under 5 in sub-Saharan Africa. CM is characterized by seizures and impaired consciousness that lead to death in 15-20% of cases if treated quickly, but it is completely fatal when untreated. Brain magnetic resonance imaging (MRI) is an invaluable source of information on the pathophysiology of brain damage, but, due to limited access to scanners in endemic regions, only until very recently have case reports of CM patients studied with advanced MRI methods been published.
View Article and Find Full Text PDFTranscriptomic profiling of "brain-eating amoeba" infection in mice: the host and the protozoa perspectives.
Front Cell Infect Microbiol
December 2024
Institut Pasteur de la Guadeloupe, Les Abymes, Guadeloupe, France.
The free-living amoeba (NF) causes a rare but lethal parasitic meningoencephalitis (PAM) in humans. Currently, this disease lacks effective treatments and the specific molecular mechanisms that govern NF pathogenesis and host brain response remain unknown. To address some of these issues, we sought to explore naturally existing virulence diversity within environmental NF isolates.
View Article and Find Full Text PDFSeroprevalence of Naegleria fowleri in the Houston-Galveston Texas Population.
Parasitol Res
December 2024
Department of Clinical Laboratory Sciences, School of Health Professions, Medical Branch, University of Texas, 301 University Blvd, Galveston, TX, 77555-0128, USA.
Naegleria fowleri is a free-living amoeba and the causative agent of Primary Amebic Meningoencephalitis (PAM), a rare yet almost always fatal disease that primarily affects children. While only 431 PAM cases have been reported worldwide, the southern states of the United States, including Texas, report the highest number of cases. Despite the high mortality of the disease, studies have identified antibodies to N.
View Article and Find Full Text PDFThe effect of bitter honey against cerebral malaria-induced inflammasome cell death: network pharmacology-based in silico evaluation.
Biomed Khim
December 2024
Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria; College of Health Sciences, Osun State University, Osogbo, Osun State, Nigeria.
Cerebral malaria (CM) is a fatal complication of Plasmodium falciparum infection. The biological and physiological links between CM, inflammation, and inflammasome, point to the complexity of its pathology. Resistance to available and affordable drugs, worsening economic crisis, and urgent need for integration of orthodox with traditional/alternative medicine, actualized the search for sustainable pharmacotherapy.
View Article and Find Full Text PDF[Balamuthia mandrillaris amebic encephalitis: report of a case].
Zhonghua Bing Li Xue Za Zhi
December 2024
Department of Pathology, Affiliated Hospital of Hebei University, Baoding071000, China.
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