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The aim of this study was to examine the effect of aPDT with visual light (VIS) + water-filtered infrared A (wIRA) as a light source, and tetrahydroporphyrin-tetratosylate (THPTS) as a photosensitizer on in situ initial and mature oral biofilms. The samples were incubated, ex situ, with THPTS for two minutes, followed by irradiation with 200 mW cm - 2 VIS + wIRA for five minutes at 37 °C. The adherent microorganisms were quantified, and the biofilm samples were visualized using live/dead staining and confocal laser scanning microscopy (CLSM). The THPTS-mediated aPDT resulted in significant decreases in both the initially adherent microorganisms and the microorganisms in the mature oral biofilms, in comparison to the untreated control samples (>99.99% each; = 0.018 and = 0.0066, respectively). The remaining vital bacteria significantly decreased in the aPDT-treated biofilms during initial adhesion (vitality rate 9.4% vs. 71.2% untreated control, 17.28% CHX). Of the mature biofilms, 25.67% remained vital after aPDT treatment (81.97% untreated control, 16.44% CHX). High permeability of THPTS into deep layers could be shown. The present results indicate that the microbial reduction in oral initial and mature oral biofilms resulting from aPDT with VIS + wIRA in combination with THPTS has significant potential for the treatment of oral biofilm-associated diseases.
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http://dx.doi.org/10.3390/microorganisms9010145 | DOI Listing |
Mol Microbiol
December 2024
Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, Florida, USA.
Queuosine (Q) is a modification of the wobble base in tRNAs that decode NA(C/U) codons. It is ubiquitous in bacteria, including many pathogens. Streptococcus mutans is an early colonizer of dental plaque biofilm and a key player in dental caries.
View Article and Find Full Text PDFShanghai Kou Qiang Yi Xue
October 2024
Department of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology. Shanghai 200011, China. E-mail:
Purpose: To explore the differences between plaque biofilms of children with different caries activities via metabolomics.
Methods: A case-control study was conducted to investigate the oral health-related behaviors of children in caries-free (CF), low level of early childhood caries(LECC) and high level of early childhood caries (HECC) groups and to collect supragingival plaque biofilms. Untargeted metabolomics was used to detect the compositions of plaque biofilm metabolites in three groups.
NPJ Biofilms Microbiomes
December 2024
Department of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, Germany.
Biofilm-associated peri-implant infections pose a major problem in modern medicine. The understanding of biofilm development is hampered by biofilm complexity and the lack of robust clinical models. This study comprehensively characterized the dynamics of early biofilm formation in the transmucosal passage of implant abutments in 12 patients.
View Article and Find Full Text PDFEur Arch Paediatr Dent
December 2024
Department of Pediatric Dentistry, Faculty of Dentistry, Mahidol University, 6 Yothee Street, Ratchathewi, Bangkok, 10400, Thailand.
Aims: To quantitatively detect S. mutans, Bifidobacterium, and S. wiggsiae in occlusal biofilm from permanent first molars based on the Visible Occlusal Plaque Index (VOPI), and to analyse the association between their levels and the occlusal enamel caries occurrence following the diagnosis of the International Caries Detection and Assessment System (ICDAS).
View Article and Find Full Text PDFChem Biodivers
December 2024
Saveetha University - Poonamallee Campus: SIMATS Deemed University, Biochemistry, Ponnamallee, 600077, Chennai, INDIA.
The fungus Candida albicans is a prominent cariogenic fungal agent that works in association with Streptococcus mutans to accelerate the formation of oral cancer and tooth decay. This study evaluates caffeine-encapsulated titanium oxide nanoparticles (CF-TiO2 NPs) for their potential to prevent biofilm formation on teeth and enhance oral anticancer treatment by influencing apoptotic gene regulation. The synthesized CF-TiO2 NPs were characterized using UV, SEM, EDAX, and FTIR analyses, and their antioxidant activity was confirmed through free radical quenching studies.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!