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Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only. | LitMetric

AI Article Synopsis

  • Aluminum hydroxide is commonly used as an adjuvant in sheep vaccines, but it may contribute to a condition called ASIA syndrome, which causes severe wasting in sheep.
  • A study involving four flocks of lambs examined the effects of repeated aluminum hydroxide injections, showing slight reductions in growth but no significant health issues in clinical or hematological measures.
  • While some neurological and injection-related side effects were noted, the study concluded that aluminum hydroxide alone is not sufficient to cause the full spectrum of ASIA syndrome, suggesting other factors may also be influential.

Article Abstract

Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep-the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characterize the effects of the repetitive injection of Al-hydroxide containing products in lambs. Four flocks (Flocks 1-4; = 21 each) kept under different conditions were studied. Three groups of seven lambs (Vaccine, Adjuvant-only, and Control) were established in each flock. Mild differences in average daily gain and fattening index were observed, indicating a reduced growth performance in Vaccine groups, likely related to short-term episodes of pyrexia and decreased daily intake. Clinical and hematological parameters remained within normal limits. Histology showed no significant differences between groups, although there was a tendency to present a higher frequency of hyperchromatic, shrunken neurons in the lumbar spinal cord in the Adjuvant-only group. Although Al-hydroxide was linked to granulomas at the injection site and behavioral changes in sheep, the results of the present experimental work indicate that injected Al-hydroxide is not enough to fully reproduce the wasting presentation of the ASIA syndrome. Other factors such as sex, breed, age, production system, diet or climate conditions could play a role.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827811PMC
http://dx.doi.org/10.3390/ani11010146DOI Listing

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