AI Article Synopsis
- Researchers developed a high-pressure compression-molded (HPCM) porous scaffold using poly(l-lactide) (PLLA), poly(lactide-glycolide) (PLGA), and hydroxyapatite (HA) to address bone defect healing challenges.
- The scaffold demonstrated impressive mechanical properties with a compressive yield strength of 0.91 MPa and modulus of 6.84 MPa due to its solid network structure and crystalline arrangement.
- Additionally, the HPCM scaffold featured over 80% porosity, suitable degradation rates, increased cell proliferation, and successfully promoted healing in a rat calvarial defect model.
Article Abstract
Fabricating porous scaffolds with sufficient mechanical properties is a challenge for healing bone defects. High-pressure compression-molded (HPCM) porous composite scaffold comprising poly(l-lactide) (PLLA), poly(lactide--glycolide) (PLGA), and hydroxyapatite (HA) was prepared and showed upregulated mechanical properties due to a solid network structure and a highly ordered crystalline architecture. The compressive yield strength and modulus of the HPCM scaffold molded at 1000 MPa and 180 °C were 0.91 and 6.84 MPa, respectively. The HPCM scaffold also exhibited an interconnected porous architecture with porosity greater than 80%, an appropriate degradation rate, and enhanced cell proliferation. Moreover, the HPCM scaffold supported the healing of a rat calvarial defect in vivo.
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| http://dx.doi.org/10.1021/acsbiomaterials.6b00202 | DOI Listing |
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