AI Article Synopsis
- - The study focused on chronic idiopathic axonal polyneuropathy (CIAP), examining how quickly the condition worsens and how genetic factors, particularly the HLA-DQA1*05 allele, might influence its development.
- - Out of 57 patients analyzed over an average of 7 years, the DQA1*05 allele was notably more common in those with CIAP compared to healthy individuals, suggesting a potential genetic link.
- - The findings indicated that patients with length-dependent CIAP experience a steady decline in nerve function over time, with significant annual decreases in nerve amplitudes, highlighting the need for further research into the role of the immune system in CIAP.
Article Abstract
Background: We aimed to describe the electrophysiological progression rate of chronic idiopathic axonal polyneuropathy (CIAP) and look into the potential role of human leukocyte antigen (HLA) genetic susceptibility in its development.
Methods: We recruited 57 patients with CIAP (mean age at diagnosis 67, mean follow-up 7 years). The assessments included clinical and electrophysiological data and HLA-DQ genotyping.
Results: The DQA1*05 allele was found more frequently in patients than in healthy controls (odds ratio, 1.96, P = .011). In patients with length-dependent CIAP, a linear effect of time on the electrophysiological findings was found in the superficial radial (3.2% mean annual decrement, P < .001), sural (4.7% mean annual decrement, P = .002) and tibial nerve (6.1% mean annual decrement, P = .007) amplitudes, independently from age or gender.
Conclusions: Patients with length-dependent CIAP, show a linear progression over time. Interesting associations of HLA-DQA1*05 allele with length-dependent CIAP and non-DQ2/DQ8 with idiopathic sensory ganglionopathy were found. These merit further investigation in larger cohorts and may suggest a role of the immune system in the pathogenesis of CIAP.
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| http://dx.doi.org/10.1002/mus.27164 | DOI Listing |
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