AI Article Synopsis
- The study analyzed the transcriptomic host response to SARS-CoV-2 in patients with COVID-19, comparing it to responses from other viral infections using RNA sequencing.
- Results showed that although COVID-19 gene expression changes were significantly correlated with other viral infections, there were 416 genes unique to COVID-19, indicating specific immune responses and evasion mechanisms.
- The findings reveal shifts in immune cell types during COVID-19, with increases in natural killer cells and M2 macrophages, helping to deepen our understanding of how the host responds to SARS-CoV-2.
Article Abstract
The pandemic 2019 novel coronavirus disease (COVID-19) shares certain clinical characteristics with other acute viral infections. We studied the whole-blood transcriptomic host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using RNAseq from 24 healthy controls and 62 prospectively enrolled patients with COVID-19. We then compared these data to non-COVID-19 viral infections, curated from 23 independent studies profiling 1,855 blood samples covering six viruses (influenza, respiratory syncytial virus (RSV), human rhinovirus (HRV), severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Ebola, dengue). We show gene expression changes in COVID-19 versus non-COVID-19 viral infections are highly correlated (r = 0.74, p < 0.001). However, we also found 416 genes specific to COVID-19. Inspection of top genes revealed dynamic immune evasion and counter host responses specific to COVID-19. Statistical deconvolution of cell proportions maps many cell type proportions concordantly shifting. Discordantly increased in COVID-19 were CD56 natural killer cells and M2 macrophages. The concordant and discordant responses mapped out here provide a window to explore the pathophysiology of the host response to SARS-CoV-2.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786129 | PMC |
| http://dx.doi.org/10.1016/j.isci.2020.101947 | DOI Listing |
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