AI Article Synopsis
- The study focuses on the significance of magnetic dipole coupling between superparamagnetic nanoparticles and how their concentration affects Specific Loss Power (SLP) in magnetic nanofluid hyperthermia (MNFH).
- Despite extensive research, the reasons behind the concentration-dependent changes in SLP are still not fully understood, leading to some inconsistent findings.
- The authors identify energy competition among various magnetic energy types as the key factor driving the oscillation behavior of SLP, offering important insights for effectively using MNFH in cancer treatment.
Article Abstract
Magnetic dipole coupling between the colloidal superparamagnetic nanoparticles (SPNPs) depending on the concentration has been paid significant attention due to its critical role in characterizing the Specific Loss Power (SLP) in magnetic nanofluid hyperthermia (MNFH). However, despite immense efforts, the physical mechanism of concentration-dependent SLP change behavior is still poorly understood and some contradictory results have been recently reported. Here, we first report that the SLP of SPNP MNFH agent shows strong concentration-dependent oscillation behavior. According to the experimentally and theoretically analyzed results, the energy competition among the magnetic dipole interaction energy, magnetic potential energy, and exchange energy, was revealed as the main physical reason for the oscillation behavior. Empirically demonstrated new finding and physically established model on the concentration-dependent SLP oscillation behavior is expected to provide biomedically crucial information in determining the critical dose of an agent for clinically safe and highly efficient MNFH in cancer clinics.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804452 | PMC |
| http://dx.doi.org/10.1038/s41598-020-79871-1 | DOI Listing |
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