AI Article Synopsis
- The zebrafish is a key model for studying biomechanics and the effects of food toxicity, particularly through its tail movements during swimming.
- A new microfluidic device with a shape memory alloy actuator was created to study the zebrafish's hydrodynamic responses while being exposed to food additives.
- By analyzing the zebrafish's behavior during early development, this research offers valuable insights for using zebrafish in drug discovery and understanding human health responses.
Article Abstract
The zebrafish is acknowledged as a reliable species of choices for biomechanical-related investigations. The definite quantification of the hydrodynamic flow physics caused by behavioral patterns, particularly in the zebrafish tail beat, is critical for a comprehensive understanding of food toxicity in this species, and it can be further interpreted for possible human responses. The zebrafish's body size and swimming speed place it in the intermediate flow regime, where both viscous and inertial forces play significant roles in the fluid-structure interaction. This pilot work highlighted the design and development of a novel microfluidic device coupled with a shape memory alloy (SMA) actuator to immobilize the zebrafish within the observation region for hydrodynamic quantification of the tail-beating behavioral responses, which may be induced by the overdose of food additive exposure. This study significantly examined behavioral patterns of the zebrafish in early developmental stages, which, in turn, generated vortex circulation. The presented findings on the behavioral responses of the zebrafish through the hydrodynamic analysis provided a golden protocol to assess the zebrafish as an animal model for new drug discovery and development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827268 | PMC |
| http://dx.doi.org/10.3390/mi12010068 | DOI Listing |
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