A self-responsive insulin delivery system is highly desirable because of its high sensitivity dependent on blood glucose levels. Herein, a smart pH-triggered and glucose-mediated transdermal delivery system, insulin-loaded and ZnO quantum dots (ZnO QDs) capped mesoporous bioactive glasses (MBGs) integrated with microneedles (MNs), was developed to achieve control and painless administration. ZnO QDs as a promise pH-responsive switch were employed to cap the nanopores of MBGs via electrostatic interaction. The drug (insulin) and glucose-responsive factor (glucose oxidase/catalase, GO/CAT) were sealed into the pores of MBGs. GO/CAT in the MBGs could catalyze glucose to form gluconic acid, resulting decrease in the local pH. The ZnO QDs on the surface of the MBGs could be dissolved in the acidic condition, leading to disassembly of the pH-sensitive MBGs and then release of preloaded insulin from the MBGs. As a result of administration in a diabetic model, an excellent hypoglycemic effect and lower hypoglycemia risk were obtained. These results indicate that as-prepared pH-triggered and glucose-mediated transdermal delivery systems have hopeful applications in the treatment of diabetes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsbiomaterials.8b00626 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Microwave-Assisted Synthesized ZnO@APTES Quantum Dots Exhibits Potent Antibacterial Efficacy Against Methicillin-Resistant Without Inducing Resistance.
Int J Nanomedicine
January 2025
Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, People's Republic of China.
Background: Antibiotic resistance of many bacteria, including Methicillin-resistant (MRSA), has become a major threat to global health. Zinc Oxide Quantum dots (ZnO-QDs) show good antibacterial activity, but most of them are insoluble in water, limiting their application range, and there is a lack of research on drug resistance inducement.
Methods: The water-soluble zinc oxide quantum dots modified by APTES (ZnO@APTES QDs) were prepared by a microwave assisted synthesis.
Synergistic Improvement of Narrow Bandgap PbS Quantum Dot Solar Cells through Surface Ligand Engineering, Near-Infrared Spectral Matching, and Enhanced Electrode Transparency.
ACS Appl Mater Interfaces
January 2025
CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.
The tunability of the energy bandgap in the near-infrared (NIR) range uniquely positions colloidal lead sulfide (PbS) quantum dots (QDs) as a versatile material to enhance the performance of existing perovskite and silicon solar cells in tandem architectures. The desired narrow bandgap (NBG) PbS QDs exhibit polar (111) and nonpolar (100) terminal facets, making effective surface passivation through ligand engineering highly challenging. Despite recent breakthroughs in surface ligand engineering, NBG PbS QDs suffer from uncontrolled agglomeration in solid films, leading to increased energy disorder and trap formation.
View Article and Find Full Text PDFOptical tuning of polymer functionalized zinc oxide quantum dots as a selective probe for the detection of antibiotics.
Sci Rep
January 2025
Special Centre for Nanoscience, Jawaharlal Nehru University, New Delhi, 110067, India.
Excess consumption of antibiotics leads to antibiotic resistance that hinders the control and cure of microbial diseases. Therefore, it is crucial to monitor the antibiotic levels in the environment. In this proposed research work, an optical nano-sensor was devised that can sense the ultra-low concentration of antibiotics, in samples like tap water using fluorescent zinc oxide quantum dots (ZnO QDs) based nano-sensor.
View Article and Find Full Text PDFSupercycle Al-Doped ZnMgO Alloys via Atomic Layer Deposition for Quantum Dot Light-Emitting Diodes.
ACS Appl Mater Interfaces
January 2025
Department of Photonics and Nanoelectronics, and BK21 FOUR ERICA-ACE Center, Hanyang University, Ansan 15588, Korea.
Colloidal quantum-dot light-emitting diodes (QD-LEDs) have been significantly improved in terms of device performance and lifetime by employing zinc oxide (ZnO) as an electron transport layer (ETL). Although atomic layer deposition (ALD) allows fabrication of uniform, high-quality ZnO films with minimal defects, the high conductivity of ZnO has hindered its straightforward application as an ETL in QD-LEDs. Herein, we propose fabrication of Al-doped ZnMgO (Al:ZnMgO) ETLs for QD-LEDs through a supercycle ALD, with alternating depositions of various metal oxides.
View Article and Find Full Text PDFIn-situ and ex-situ EPS-corona formation on ZnO QDs mitigates their environmental toxicity in the freshwater microalgae Chlorella sp.
J Hazard Mater
December 2024
Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore, Tamil Nadu, India. Electronic address:
The current work seeks to understand how the interactions between ZnO QDs and extracellular polymeric substances (EPS) may vary based on the types of EPS (loosely and tightly bound) and modes of eco-corona formation (In-situ or ex-situ). In-situ eco-corona refers to formation of an EPS layer on the QDs during the interactions with the algae whereas the ex-situ condition refers to forming the layer before the interactions. ZnO QDs were added at 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!