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Intrinsic and Extrinsic Methods for Augmenting Fracture Healing in the Hand and Wrist.
Cureus
December 2024
Department of Orthopedic Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, USA.
This review examines intrinsic and extrinsic augmentation techniques for uniting hand and upper extremity fractures, including bone morphogenic proteins (BMPs), platelet-rich plasma (PRP), low-intensity pulsed ultrasound (LIPUS), and pulsed electromagnetic fields (PEMF). While BMPs, PRP, LIPUS, and PEMF show potential in accelerating bone healing and reducing nonunion rates, their clinical adoption is limited by high costs and inconsistent results. This paper focuses on understanding the efficacy of these techniques, their drawbacks, and potential next steps for the field.
View Article and Find Full Text PDFIntra-Articular Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Hip Osteoarthritis: A Cross-Sectional Analysis of the Overlapping Systematic Reviews.
Ther Clin Risk Manag
December 2024
Department of Spine Surgery, Ganzhou People's Hospital, Ganzhou, People's Republic of China.
Purpose: The debate over the effectiveness of platelet-rich plasma (PRP) versus hyaluronic acid (HA) in treating hip osteoarthritis (HOA) continues. This cross-sectional analysis of overlapping systematic reviews aims to evaluate the efficacy of intra-articular PRP compared to HA for HOA treatment. The goal is to guide decision-makers in selecting the most reliable systematic reviews and to provide treatment recommendations based on the best available evidence.
View Article and Find Full Text PDFBackground And Aims: Metformin is a widely used oral agent for controlling diabetes mellitus, but it also has other therapeutic benefits for various conditions. In addition, conventional oral metformin, and topical metformin have been used in, in-vitro studies in the treatment of acne, psoriasis, wound healing, and and so forth. While topical metformin has shown promising results in animal studies, there is limited data on its effectiveness in humans.
View Article and Find Full Text PDFPlatelet-Rich Plasma in Diabetic Foot Ulcer Healing: Contemplating the Facts.
Int J Mol Sci
November 2024
Department of Translational Research, Western University of Health Sciences, Pomona, CA 91766, USA.
Diabetic foot ulcers (DFUs), debilitating complication of diabetes, often lead to amputation even in the presence of current advanced treatment for DFUs. Platelet-rich plasma (PRP) containing growth factors and other proteins has been suggested as a potent therapeutic in promoting DFU healing. PRP is safe and effective in improving the DFU healing rate, decreasing healing time, and making chronic wounds viable for treatment.
View Article and Find Full Text PDFInterventions for recurrent embryo implantation failure: An umbrella review.
Int J Gynaecol Obstet
December 2024
Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Granada, Granada, Spain.
Article Synopsis
- A systematic review was conducted to evaluate various interventions for recurrent implantation failure (RIF), summarizing findings from randomized clinical trials (RCTs) related to treatment effectiveness in terms of clinical pregnancy rates (CPR) and live birth rates (LBR).
- A total of 47 systematic reviews were analyzed, revealing that most had low methodological quality and inconsistencies, highlighting issues like overlap of RCTs and varied definitions of RIF across studies.
- Granulocyte colony-stimulating factor (G-CSF), intralipid infusion, and peripheral blood mononuclear cells (PBMC) showed significant impacts on CPR and LBR, indicating potential benefits from these treatments based on the GRADE strength assessment.
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