The Feasibility of Cu-PSMA I&T PET for Prostate Cancer.

Cancer Biother Radiopharm

Department of Nuclear Medicine, Korea Cancer Centre Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.

Published: August 2022

The goal of this research was to investigate the feasibility of Cu labeling in prostate-specific membrane antigen imaging and therapy (PSMA I&T) for PSMA positron emission tomography (PET) imaging and biodistribution evaluation. PSMA I&T was labeled with Cu, and stability in human and mouse sera was evaluated. Prostate cancer cell lines were used for specific uptake assays (22RV1 for PSMA-positive, PC-3 for -negative). Both PC-3 and 22RV1 cells were transplanted into the left and right thighs in a mouse for PET/computed tomography (CT) imaging. Biodistribution was performed using 22RV1 tumor models. Labeling yield (decay corrected) of Cu-PSMA I&T was more than 95% compared to the free Cu peak. The serum stability of Cu-PSMA I&T was maintained at more than 90% until 60 h. Regarding the specific binding of Cu-PSMA I&T was 7.5-fold higher to 22RV1 cells than PC-3 cells ( < 0.001). On PET/CT imaging, more specific Cu-PSMA I&T uptake was observed to 22RV1 tumors than to PC-3 tumors. In the PSMA blocking study using 2-phosphonomethoxypropyl adenine (2-PMPA), the Cu-PSMA I&T signal significantly decreased in the 22RV1 tumor region. In the biodistribution study, the kidney uptake was the highest among all organs at 2 h (52.6 ± 20.8%ID/g) but sharply decreased at 24 and 48 h. Also, the liver showed similar uptake over time (range, 10-12%ID/g). On the contrary, Cu-PSMA I&T uptake of the tumors increased with time and peaked at 48 h (5.6 ± 0.1%ID/g). PSMA I&T labeled with Cu showed the feasibility of the PSMA specific PET imaging through and studies. Furthermore, Cu-PSMA I&T might be considered as the candidate of future clinical trial.

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http://dx.doi.org/10.1089/cbr.2020.4189DOI Listing

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